1. Metabolic Enzyme/Protease
    Epigenetics
    Cell Cycle/DNA Damage
  2. Phosphodiesterase (PDE)
    HDAC
  3. CM-675

CM-675 

Cat. No.: HY-114303
Handling Instructions

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease.

For research use only. We do not sell to patients.

CM-675 Chemical Structure

CM-675 Chemical Structure

CAS No. : 1872466-47-1

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Description

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].

IC50 & Target[1]

HDAC1

673 nM (IC50, 30 min (time-dependent))

PDE5

114 nM nM (IC50)

In Vitro

CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours) [1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

536.62

Formula

C₃₁H₃₂N₆O₃

CAS No.

1872466-47-1

SMILES

O=C(NC1=CC=CC=C1N)C2=CC=C(CC3=CC=C(OCC)C(C4=NC5=C(N(C)N=C5CCC)C(N4)=O)=C3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
CM-675
Cat. No.:
HY-114303
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CM-675

Cat. No.: HY-114303