NHNB 

NHNB is a selective HDAC8 inhibitor (IC₅₀ = 66.0 μM) and Peptidoglycan N-acetylglucosamine (GlcNAc) deacetylases (PGNGdacs) inhibitor. NHNB shows antibacterial and bactericidal activity against B. anthracis and B. cereus. NHNB can be used for the research of acute myeloid leukemia, Bacillus anthracis infection, and Bacillus cereus infection^[1][2].

NHNB (Compound 4) inhibits recombinant human HDAC8 with an IC₅₀ of 66.0 μM^[1].
NHNB (0-5000 μM; 5 min) acts as a competitive inhibitor of purified B. cereus BC1974 peptidoglycan deacetylase with an IC₅₀ of 43.3 μM and a K_i of 8.7 μM^[2].
NHNB (0-5000 μM; 10 min) acts as a competitive inhibitor of purified B. cereus BC1960 peptidoglycan deacetylase with an IC₅₀ of 132 μM and a K_i of 66.0 μM^[2].
NHNB (4 μg/mL; 16 h) induces onger chains of daughter cell production in B. cereus and B. anthracis^[2].
NHNB shows MICs of 5.26-7.89 μg/mL and MBcs of 8.23 μg/mL for B. cereus ATCC
14,579 and B. anthracis 7702^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

263.29

C₁₇H₁₃NO₂

106359-61-9

O=C(C1=CC=C(C2=CC=CC3=C2C=CC=C3)C=C1)NO

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007;17(10):2874-2878.  [Content Brief]

  [2]. Balomenou S, et al. Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus. Bioorg Med Chem. 2018;26(13):3845-3851.  [Content Brief]