106359-61-9
106359-61-9
Chemical Structure
NHNB
- CAS No.: 106359-61-9
- Formula:C17H13NO2
- Molecular Weight:263.29
IUPAC Name: N-hydroxy-4-(naphthalen-1-yl)benzamide
InChIKey: PKQVYJOPUCLLCD-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=CC3=C2C=CC=C3)C=C1)NO
Biological Activity: NHNB is a selective HDAC8 inhibitor (IC50 = 66.0 μM) and Peptidoglycan N-acetylglucosamine (GlcNAc) deacetylases (PGNGdacs) inhibitor. NHNB shows antibacterial and bactericidal activity against B. anthracis and B. cereus. NHNB can be used for the research of acute myeloid leukemia, Bacillus anthracis infection, and Bacillus cereus infection[1][2].
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NHNB | NHNB is a selective HDAC8 inhibitor (IC50 = 66.0 μM) and Peptidoglycan N-acetylglucosamine (GlcNAc) deacetylases (PGNGdacs) inhibitor. NHNB shows antibacterial and bactericidal activity against B. anthracis and B. cereus. NHNB can be used for the research of acute myeloid leukemia, Bacillus anthracis infection, and Bacillus cereus infection. | |||||||||||||||||||||
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References
- [1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007;17(10):2874-2878. [Content Brief]
- [2]. Balomenou S, et al. Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus. Bioorg Med Chem. 2018;26(13):3845-3851. [Content Brief]
Keywords
