Fast green FCF free acid
Based on 1 publication(s) in Google Scholar
Fast green FCF free acid is a dye that is acid-resistant. Fast Green FCF free acid inhibits α-synuclein aggregation, as well as Aβ, P2X4 receptor and TLR4/Myd88/NF-κB. Fast Green FCF free acid is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF free acid improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function.
For research use only. We do not sell to patients.
- CAS No.: 25738-40-3
- Formula: C37H36N2O10S3
- Molecular Weight:764.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Fast green FCF free acid
MoreAll α-synuclein Isoforms
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Biological Activity
Description
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α-synuclein Aggregation |
In Vitro
Fast Green FCF free acid (molar ratios of HEWL/FCF free acid: 1 to 0.01-1 to 1, 10 days) free acid suppresses the generation of lysozyme fibrils in a concentration-dependent manner and exhibits disaggregating activity against the preformed/existing lysozyme fibrils[2].
Fast Green FCF (100 μg/mL-1 mg/mL) free acid inhibits synaptic activity in rat hippocampal interneurons, with half-maximum effective concentration of ~200 μg/mL (250 μM)[3].
Fast Green FCF (5-100 μM, 24 h) free acid inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity in PC12 cells[4].
Fast green FCF (molar ratios of Aβ40 to FGF of 3:1-1:3) free acid alleviates the cytotoxicity induced by Aβ40 fibrillogenesis in PC12 cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells with α-syn fibrils
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Concentration:5, 25, 50, 100 μM
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Incubation Time:24 h
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Result:Reduced the cytotoxicity, and the cell viability respectively reached 66.2% (5 μM) and 72.7% (25 μM).
Increased cell viability, reaching 76.4% (50 μM) and 89.0% (100 μM), respectively.
In Vivo
Fast Green FCF (10-100 mg/kg, i.p., once daily, 30 min before surgery) free acid prevents postoperative cognitive dysfunction via the downregulation of the P2X4 receptor in mice[6].
Fast Green FCF (100 mg/kg, i.p., daily for 7 days) free acid attenuates lipopolysaccharide-induced depressive-like behavior and downregulates TLR4/Myd88/NF-κB signal pathway in the mouse hippocampus[7].
Fast Green FCF (30-100 mg/kg, i.p., daily for 9 days) free acid alleviates pain hypersensitivity and down-regulates the levels of spinal P2X4 expression and pro-inflammatory cytokines in a rodent inflammatory pain model[8].
Fast Green FCF (0.017-0.041 gm per kg body weight, p.o., 42 days) free acid causes a significant decrease in testicular weight, tubular diameter, sperm density, and sperm motility[9].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Aβ-induced cognitive impairment mice[5]
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Dosage:30, 100 mg/kg
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Administration:Intraperitoneal injection (i.p.), 30 min prior to each trial
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Result:Did not alter the recognition index.
Prevented the Aβ42-induced recognition impairment at 100 mg/kg.
Prevented the Aβ42-induced impairment of spatial learning at 100 mg/kg.
reduced the Aβ42-induced memory impairment.
Chemical Information
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CAS No. 25738-40-3
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Molecular Weight 764.88
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Formula C37H36N2O10S3
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SMILES
O=S(C1=CC(C/[N+](CC)=C2C=C/C(C=C/2)=C(C3=CC=C(N(CC)CC4=CC=CC(S(=O)(O)=O)=C4)C=C3)\C5=CC=C(O)C=C5S(=O)(O)=O)=CC=C1)([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Purity & Documentation
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fast green FCF free acid Related Classifications
HY-D0914A Related Classifications
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