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KAT6A Antibody (YA6622)(PBS only)

(Synonyms: Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 ZNF220 )

KAT6A Antibody (YA6622)(PBS only)is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KAT6A.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IHC-P, FC, ChIP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS.

  • Conjugation:
    Non-conjugated
  • KAT6A Antibody (YA6622)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
ChIP Info
ChIP: Chromatin Immunoprecipitation
Dilution Ratio 1:2000 1:500 1:2000-1:20000 1:200-1:1000 Use 5 μg for 25 μg of chromatin.

Product Details

Description

KAT6A Antibody (YA6622)(PBS only)is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KAT6A.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 225 kDa
Immunogen

Recombinant protein within human KAT6A aa 785-1,034.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3719229

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    KAT6A is a Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. May play a role in leukemogenic gene transcription[1][2][3][4][5].

  • Subcellular Localization

    Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body

  • Expression


    PositiveControl: Huh7, human liver tissue, human placenta tissue, mouse liver tissue, mouse placenta tissue, rat liver tissue.

  • Isoforms & Post-Translational Modification

    KAT6A has an amino acid length of 2004, molecular weight is 225028 Da.
    Autoacetylated; autoacetylation at Lys-604 is required for proper function. Acetylation at Lys-1007 and Lys-1014 is required for the interaction with MLLT1/ENL and MLLT3/AF9.

  • Subunit

    Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.

  • SwissProt ID

    Q92794

  • Gene ID
    7994 [NCBI]
  • Synonyms

    Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 ZNF220

References

[1]. Kitabayashi I, et al. Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. EMBO J. 2001 Dec 17;20(24):7184-96. [Content Brief]

[2]. Pelletier N, et al. MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Oncogene. 2002 Apr 18;21(17):2729-40. [Content Brief]

[3]. Bristow CA, et al. Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ. Nucleic Acids Res. 2003 Jun 1;31(11):2735-44. [Content Brief]

[4]. Rokudai S, et al. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3895-900. [Content Brief]

[5]. Becht DC, et al. A multivalent engagement of ENL with MOZ. Nat Struct Mol Biol. 2025 Apr;32(4):709-718. [Content Brief]

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KAT6A Antibody (YA6622)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • KAT6A Antibody (YA6622)(PBS only) Product Image