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  3. Molibresib besylate

Molibresib besylate (Synonyms: GSK 525762C; I-BET 762 besylate)

Cat. No.: HY-13032B
Handling Instructions

Molibresib besylate (GSK 525762C; I-BET 762 besylate) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.

For research use only. We do not sell to patients.

Molibresib besylate Chemical Structure

Molibresib besylate Chemical Structure

CAS No. : 1895049-20-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 136 In-stock
Estimated Time of Arrival: December 31
5 mg USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 156 In-stock
Estimated Time of Arrival: December 31
50 mg USD 456 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Other Forms of Molibresib besylate:

Top Publications Citing Use of Products

    Molibresib besylate purchased from MCE. Usage Cited in: Oncotarget. 2016 Jun 21;7(25):38319-38332.

    iBET762 partially disrupts the interaction between full-length ERG and BRD4 (A), and between T1-E4 ERG and BRD4 (B).

    Molibresib besylate purchased from MCE. Usage Cited in: Nat Med. 2017 Sep;23(9):1055-1062.

    Western blot of WCL of C4-2 cells treated with vehicle (DMSO) or different doses of JQ1 or i-BET for 24 h. Actin is used as a loading control.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Molibresib besylate (GSK 525762C; I-BET 762 besylate) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.

    IC50 & Target

    IC50: 32.5-42.5 nM (BET)[1]

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (42.95 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7180 mL 8.5900 mL 17.1801 mL
    5 mM 0.3436 mL 1.7180 mL 3.4360 mL
    10 mM 0.1718 mL 0.8590 mL 1.7180 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.67 mg/mL (4.59 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.67 mg/mL (4.59 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.67 mg/mL (4.59 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Molecular Weight

    582.07

    Formula

    C₂₈H₂₈ClN₅O₅S

    CAS No.

    1895049-20-3

    SMILES

    ClC1=CC=C(C2=N[[email protected]@H](CC(NCC)=O)C3=NN=C(C)N3C4=CC=C(OC)C=C24)C=C1.O=S(C5=CC=CC=C5)(O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Molibresib besylate
    Cat. No.:
    HY-13032B
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    Molibresib besylate

    Cat. No.: HY-13032B