2-Fluorophenylboronic acid
Based on 1 Customer Validation
2-Fluorophenylboronic acid is an organic synthesis intermediate belonging to the fluorinated arylboronic acid class. The electron-withdrawing fluorine substituent in 2-Fluorophenylboronic acid reduces its pKa, thereby enhancing boronate bond formation with diols. 2-Fluorophenylboronic acid serves as a key synthetic intermediate for inhibitors of Plasmodium phosphatidylinositol 4-kinase IIIβ (PI4K). 2-Fluorophenylboronic acid can also be used to functionalize linear polyglycerols for constructing dual dynamic covalent cross-linked hydrogels that support 3D tumor spheroid culture of various cancer cells. 2-Fluorophenylboronic acid is applicable to research related to malaria and tumors.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.99%
- CAS. Nr.: 1993-03-9
- Formel: C6H6BFO2
- Molecular Weight:139.92
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-I0201
4-Fluorobenzeneboronic acid -
HY-W001090
Phenylboronic acid -
HY-W002177
4-Methoxyphenylboronic acid -
HY-32902
3-(Trifluoromethyl)phenylboronic acid -
HY-W001232
2-Tolylboronic acid -
HY-W007381
3-Tolylboronic acid -
HY-W002569
2-Methoxyphenylboronic acid -
HY-76584
4-Phenoxyphenylboronic acid -
HY-W007413
3-Nitrophenylboronic acid -
HY-59219
Cyclopropylboronic acid -
HY-75129
Pyridin-3-ylboronic acid -
HY-W000978
2-Methylpropylboronic acid
Biologische Aktivität
Beschreibung
In Vitro
When 2-Fluorophenylboronic acid-functionalized linear polyglycerol (lPG) is mixed with oxidized hyperbranched polyglycerol (hbPG-CHO), a dynamic hydrogel (5 wt/v%) forms via boronate ester bonds and Schiff base interactions. Its shear modulus increases with the rising number of phenylboronic acid groups, and it supports the in-situ encapsulation of various cancer cell lines and the formation of 3D tumor spheroids[1].
2-Fluorophenylboronic acid can couple with brominated imidazo[4,5-c]quinolin-2-one in the Suzuki-Miyaura coupling reaction to generate the 8-(2-fluorophenyl)-substituted PI4K inhibitor[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 1993-03-9
-
Appearance Solid
-
Molecular Weight 139.92
-
Formel C6H6BFO2
-
Color White to off-white
-
SMILES
FC1=CC=CC=C1B(O)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (714.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (286 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Feng J, et al. Dual-Dynamic Covalently Cross-Linked Polyglycerol Hydrogels for Tumor Spheroid Culture. Biomacromolecules. 2025 Jun 09;26(6):3331-3343. [Content Brief]
[2]. Dziwornu GA, et al. Novel Inhibitors of Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and Efficacy in a Humanized Mouse Malaria Infection Model. Journal of medicinal chemistry. 2025 Aug 28;68(16):17736-17751. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.1469 mL | 35.7347 mL | 71.4694 mL | 178.6735 mL |
| 5 mM | 1.4294 mL | 7.1469 mL | 14.2939 mL | 35.7347 mL | |
| 10 mM | 0.7147 mL | 3.5735 mL | 7.1469 mL | 17.8674 mL | |
| 15 mM | 0.4765 mL | 2.3823 mL | 4.7646 mL | 11.9116 mL | |
| 20 mM | 0.3573 mL | 1.7867 mL | 3.5735 mL | 8.9337 mL | |
| 25 mM | 0.2859 mL | 1.4294 mL | 2.8588 mL | 7.1469 mL | |
| 30 mM | 0.2382 mL | 1.1912 mL | 2.3823 mL | 5.9558 mL | |
| 40 mM | 0.1787 mL | 0.8934 mL | 1.7867 mL | 4.4668 mL | |
| 50 mM | 0.1429 mL | 0.7147 mL | 1.4294 mL | 3.5735 mL | |
| 60 mM | 0.1191 mL | 0.5956 mL | 1.1912 mL | 2.9779 mL | |
| 80 mM | 0.0893 mL | 0.4467 mL | 0.8934 mL | 2.2334 mL | |
| 100 mM | 0.0715 mL | 0.3573 mL | 0.7147 mL | 1.7867 mL |
2-Fluorophenylboronic acid Related Classifications
HY-W001240 Related Classifications
Powered by Bioz