2. Anti-infection
  3. Parasite
  4. SB5-171

SB5-171 is a covalent PfCLK3 inhibitor with IC50 values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria.

For research use only. We do not sell to patients.

SB5-171

SB5-171 Chemical Structure

CAS No. : 3088376-92-2

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SB5-171 Related Antibodies

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Description

SB5-171 is a covalent PfCLK3 inhibitor with IC50 values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria[1].

In Vitro

SB5-171 (Compound 14) potently inhibits recombinant full-length PfCLK3 with apparent IC50 values of 10 nM at Km ATP and 12 nM at 3 mM ATP[1].
SB5-171 (100 pM-100 μM; 72 h) potently inhibits asexual blood stage growth of P. falciparum 3D7 (EC50 = 104 nM) and chloroquine-resistant Dd2 (EC50 = 267 nM) strains[1].
SB5-171 (24-48 h) has low cytotoxicity, with a CC50 of >100 μM in HepG2 cells and 25 μM in THP-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB5-171 Related Antibodies
Molecular Weight

593.65

Formula

C29H31N5O7S
CAS No.
SMILES

O=C(O)C1=CC=C(C2=C3C(NC(C4=CC(CN5CCN(C(COS(=O)(NC)=O)=O)CC5)=CC=C4OC)=C3)=NC=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB5-171 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB5-1713088376-92-2Parasitehuman serumCys368chloroquine-resistant Dd2malariaHepG2 cellsTHP-1 cellsPlasmodium falciparumP. falciparum 3D7PfCLK3mouse hepatocytesInhibitorinhibitorinhibit

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SB5-171
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