SB5-171
SB5-171 is a covalent PfCLK3 inhibitor with IC50 values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria.
For research use only. We do not sell to patients.
- CAS No.: 3088376-92-2
- Formula: C29H31N5O7S
- Molecular Weight:593.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SB5-171 (Compound 14) potently inhibits recombinant full-length PfCLK3 with apparent IC50 values of 10 nM at Km ATP and 12 nM at 3 mM ATP[1].
SB5-171 (100 pM-100 μM; 72 h) potently inhibits asexual blood stage growth of P. falciparum 3D7 (EC50 = 104 nM) and chloroquine-resistant Dd2 (EC50 = 267 nM) strains[1].
SB5-171 (24-48 h) has low cytotoxicity, with a CC50 of >100 μM in HepG2 cells and 25 μM in THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3088376-92-2
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Molecular Weight 593.65
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Formula C29H31N5O7S
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SMILES
O=C(O)C1=CC=C(C2=C3C(NC(C4=CC(CN5CCN(C(COS(=O)(NC)=O)=O)CC5)=CC=C4OC)=C3)=NC=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB5-171 Related Classifications
HY-181544 Related Classifications
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