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Pathways Recommended: Autophagy
Results for "

autophagy

" in MedChemExpress (MCE) Product Catalog:

1364

Inhibitors & Agonists

4

Screening Libraries

20

Fluorescent Dyes

25

Biochemical Assay Reagents

40

Peptides

2

Inhibitory Antibodies

352

Natural
Products

11

Recombinant Proteins

135

Isotope-Labeled Compounds

34

Antibodies

8

Oligonucleotides

9

GMP Molecules

Cat. No. 상품명
  • HY-L029
    Autophagy Compound Library
    		1,996 compounds

    Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

    MCE provides a unique collection of 1,996 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.
  • HY-L180
    Mitophagy Compound Library
    		611 compounds

    Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms.

    MCE can provide a library of 611 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

  • HY-L155
    Mitochondrial Toxicity Compound Library
    		535 compounds

    Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.

    MCE contains 535 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.
  • HY-L051
    Ferroptosis Compound Library
    		1,194 compounds

    Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

    MCE carefully collected a unique collection of 1,194 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

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