DQ661
DQ661 is a potent PPT1 inhibitor. DQ661 is a dimeric quinacrine autophagy inhibitor. DQ661 inhibits mTORC1 activity. DQ661 decreases the protein expression of pS6K T389, pS6 S240-244. DQ661 shows anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 2027551-01-3
- Formula: C41H47Cl2N5O2
- Molecular Weight:712.75
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 2027551-01-3
-
Molecular Weight 712.75
-
Formula C41H47Cl2N5O2
-
SMILES
ClC(C=CC1=C2NCCCCCCN(CCCCCCNC3=C4C=CC(Cl)=CC4=NC5=C3C=C(OC)C=C5)C)=CC1=NC6=C2C=C(OC)C=C6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nicastri MC, et al. Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells. Mol Cell Oncol. 2017 Nov 30;5(1):e1395504. [Content Brief]
[2]. Rebecca VW, et al. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 Nov;7(11):1266-1283. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz