Autophagy activator-1
Autophagy activator-1 (Compound B2) is an autophagy activator Autophagy. Activator-1 ultimately leads to the activation of autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.
For research use only. We do not sell to patients.
- CAS No.: 99174-40-0
- Formula: C25H32O8
- Molecular Weight:460.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Autophagy activator-1 (Compound B2) (0.5-10 μM; 1-8 h) activates autophagy in MCF-7 and HEK-293 cells in a concentration- and time-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7; HEK-293
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Concentration:1, 2, 4, 6, 8 h
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Incubation Time:0.5, 1, 2, 5, 10 μM
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Result:Increased the LC3-II protein level and decreased the p62 protein level.
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Cell Line:MCF-7
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Concentration:4 h
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Incubation Time:20 μM
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Result:Increased the LC3-II/LC3-I ratio while simultaneously decreasing the p62/GAPDH ratio.
Chemical Information
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CAS No. 99174-40-0
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Molecular Weight 460.52
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Formula C25H32O8
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SMILES
CC1=C(C(C(C(C)C)=O)=C(C(CC2=C(C(C(C(C)C)=O)=C(C(C)=C2OC)O)O)=C1OC)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Autophagy activator-1 Related Classifications
HY-170667 Related Classifications
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