Autophagy activator-1
Autophagy activator-1 (Compound B2) is an autophagy activator Autophagy. Activator-1 ultimately leads to the activation of autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.
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- No. CAS: 99174-40-0
- Fòrmula: C25H32O8
- Peso molecular:460.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Autophagy activator-1 (Compound B2) (0.5-10 μM; 1-8 h) activates autophagy in MCF-7 and HEK-293 cells in a concentration- and time-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7; HEK-293
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Concentration:1, 2, 4, 6, 8 h
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Incubation Time:0.5, 1, 2, 5, 10 μM
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Result:Increased the LC3-II protein level and decreased the p62 protein level.
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Cell Line:MCF-7
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Concentration:4 h
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Incubation Time:20 μM
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Result:Increased the LC3-II/LC3-I ratio while simultaneously decreasing the p62/GAPDH ratio.
Chemical Information
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No. CAS 99174-40-0
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Peso molecular 460.52
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Fòrmula C25H32O8
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SMILES
CC1=C(C(C(C(C)C)=O)=C(C(CC2=C(C(C(C(C)C)=O)=C(C(C)=C2OC)O)O)=C1OC)O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Autophagy activator-1 Related Classifications
HY-170667 Related Classifications
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