Erythrabyssin II
Erythrabyssin II (EL-19) is a potent late-stage autophagy inhibitor that blocks the fusion of autophagosome and lysosome. Erythrabyssin II leads to the accumulation of autophagic substrates and does not impair lysosomal pH or lysosomal enzyme activity. Erythrabyssin II suppresses ovarian cancer organoid activity and induces apoptosis. Erythrabyssin II can be used for the study of ovarian cancer.
For research use only. We do not sell to patients.
- CAS No.: 77263-06-0
- Formula: C25H28O4
- Molecular Weight:392.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| ARPE-19 | GI50 |
>100 μM
Compound: 2
|
Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay
Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay
|
[PMID: 36938984] |
| Breast carcinoma cell | IC50 |
2.9 μg/mL
Compound: 53
|
Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay
Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay
|
[PMID: 28189086] |
| KB | IC50 |
5.1 μg/mL
Compound: 53
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay
|
[PMID: 28189086] |
| MCF7 | IC50 |
>30 μM
Compound: 14
|
Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
|
[PMID: 19836230] |
| MCF7 | IC50 |
>30 μM
Compound: 14
|
Cytotoxicity against human MCF7 cells by WST-1 assay
Cytotoxicity against human MCF7 cells by WST-1 assay
|
[PMID: 19836230] |
| MCF7 | IC50 |
>30 μM
Compound: 14
|
Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
|
[PMID: 19836230] |
| MDA-MB-231 | IC50 |
>30 μM
Compound: 14
|
Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
|
[PMID: 19836230] |
Chemical Information
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CAS No. 77263-06-0
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Molecular Weight 392.49
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Formula C25H28O4
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SMILES
OC1=C(C/C=C(C)\C)C=C2[C@@](OC3=C(C/C=C(C)\C)C(O)=CC=C34)([H])[C@@]4([H])COC2=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)