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Cat. No.: HY-N3855

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Erythrabyssin II

Name: Erythrabyssin II
Brand: MedChemExpress
SKU: HY-N3855
Price: 675.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Erythrabyssin II (EL-19) is a potent late-stage autophagy inhibitor that blocks the fusion of autophagosome and lysosome. Erythrabyssin II leads to the accumulation of autophagic substrates and does not impair lysosomal pH or lysosomal enzyme activity. Erythrabyssin II suppresses ovarian cancer organoid activity and induces apoptosis. Erythrabyssin II can be used for the study of ovarian cancer.

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CAS No.: 77263-06-0
화학식: C₂₅H₂₈O₄
분자량:392.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Erythrabyssin II Chemical Structure

CAS No.: 77263-06-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
ARPE-19	GI₅₀	>100 μM Compound: 2	Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay	[PMID: 36938984]
Breast carcinoma cell	IC₅₀	2.9 μg/mL Compound: 53	Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay	[PMID: 28189086]
KB	IC₅₀	5.1 μg/mL Compound: 53	Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay	[PMID: 28189086]
MCF7	IC₅₀	>30 μM Compound: 14	Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay	[PMID: 19836230]
MCF7	IC₅₀	>30 μM Compound: 14	Cytotoxicity against human MCF7 cells by WST-1 assay Cytotoxicity against human MCF7 cells by WST-1 assay	[PMID: 19836230]
MCF7	IC₅₀	>30 μM Compound: 14	Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay	[PMID: 19836230]
MDA-MB-231	IC₅₀	>30 μM Compound: 14	Cytotoxicity against human MDA-MB-231 cells by WST-1 assay Cytotoxicity against human MDA-MB-231 cells by WST-1 assay	[PMID: 19836230]

Chemical Information

CAS No. 77263-06-0
분자량 392.49
화학식 C₂₅H₂₈O₄
SMILES

OC1=C(C/C=C(C)\C)C=C2[C@@](OC3=C(C/C=C(C)\C)C(O)=CC=C34)([H])[C@@]4([H])COC2=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jing Mo, et al. Erythrabyssin II is identified as a novel late-stage autophagy inhibitor that reverses chemoresistance and promotes apoptosis in ovarian cancer. ISCIENCE (2025).

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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