Sucrose dilaurate 

Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries^[1][2][3][4].

Sucrose dilaurate (as a component of the SDL combination, a mixture of Sucrose dilaurate and sucrose dilaurate at a ratio of approximately 6:4) significantly reduces bilirubin levels when incubated in a cell-free system, inhibits hydrogen peroxide-induced bilirubin production in human tKC keratinocytes, decreases intracellular bilirubin levels in HaCaT keratinocytes, and reduces skin-bound bilirubin levels in human skin sections^[2].
Sucrose dilaurate (0.005%; 24 h) significantly induces autophagosome formation in neonatal human epidermal keratinocytes^[3].
Sucrose dilaurate (0.01%; 24 h) significantly reduces CML levels in glyceraldehyde-glycosylated neonatal human epidermal keratinocytes^[3].
Sucrose dilaurate (0.001%; 72 h) significantly inhibits the release of IGFBP3 and NGF from doxorubicin-induced senescent HaCaT keratinocytes^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

706.90

C₃₆H₆₆O₁₃

25915-57-5

O=C(CCCCCCCCCCC)OC[C@]1(O[C@@H]([C@H]([C@@H]1OC(CCCCCCCCCCC)=O)O)CO)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang J, et al. The combination of sucrose dilaurate and sucrose laurate suppresses HMGB1: an enhancer of melanocyte dendricity and melanosome transfer to keratinocytes. J Eur Acad Dermatol Venereol. 2022;36 Suppl 3:3-11.  [Content Brief]

  [2]. Fang B, et al. A Potential Role of Keratinocyte-Derived Bilirubin in Human Skin Yellowness and Its Amelioration by Sucrose Laurate/Dilaurate. Int J Mol Sci. 2022;23(11):5884. Published 2022 May 24.

  [3]. Laughlin T, et al. Autophagy activators stimulate the removal of advanced glycation end products in human keratinocytes. J Eur Acad Dermatol Venereol. 2020;34 Suppl 3:12-18.

  [4]. Hakozaki T, et al. Over-Represented Senescent Keratinocytes in Hyperpigmented Spots Promote Melanocyte Activation via IGFBP3 and NGF. Int J Mol Sci. 2025;26(21):10724. Published 2025 Nov 4.