Sucrose dilaurate
Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries.
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- No. CAS: 25915-57-5
- Fòrmula: C36H66O13
- Peso molecular:706.90
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Sucrose dilaurate (as a component of the SDL combination, a mixture of Sucrose dilaurate and sucrose dilaurate at a ratio of approximately 6:4) significantly reduces bilirubin levels when incubated in a cell-free system, inhibits hydrogen peroxide-induced bilirubin production in human tKC keratinocytes, decreases intracellular bilirubin levels in HaCaT keratinocytes, and reduces skin-bound bilirubin levels in human skin sections[2].
Sucrose dilaurate (0.005%; 24 h) significantly induces autophagosome formation in neonatal human epidermal keratinocytes[3].
Sucrose dilaurate (0.01%; 24 h) significantly reduces CML levels in glyceraldehyde-glycosylated neonatal human epidermal keratinocytes[3].
Sucrose dilaurate (0.001%; 72 h) significantly inhibits the release of IGFBP3 and NGF from doxorubicin-induced senescent HaCaT keratinocytes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:doxorubicin-induced senescent HaCaT keratinocytes
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Concentration:0.001%
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Incubation Time:72 h
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Result:Significantly suppressed the release of IGFBP3 from senescent HaCaT keratinocytes to levels similar to those released by normal keratinocytes.
Significantly suppressed the release of NGF from senescent HaCaT keratinocytes.
Chemical Information
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No. CAS 25915-57-5
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Peso molecular 706.90
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Fòrmula C36H66O13
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SMILES
O=C(CCCCCCCCCCC)OC[C@]1(O[C@@H]([C@H]([C@@H]1OC(CCCCCCCCCCC)=O)O)CO)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Wang J, et al. The combination of sucrose dilaurate and sucrose laurate suppresses HMGB1: an enhancer of melanocyte dendricity and melanosome transfer to keratinocytes. J Eur Acad Dermatol Venereol. 2022;36 Suppl 3:3-11. [Content Brief]
[2]. Fang B, et al. A Potential Role of Keratinocyte-Derived Bilirubin in Human Skin Yellowness and Its Amelioration by Sucrose Laurate/Dilaurate. Int J Mol Sci. 2022;23(11):5884. Published 2022 May 24. [Content Brief]
[3]. Laughlin T, et al. Autophagy activators stimulate the removal of advanced glycation end products in human keratinocytes. J Eur Acad Dermatol Venereol. 2020;34 Suppl 3:12-18. [Content Brief]
[4]. Hakozaki T, et al. Over-Represented Senescent Keratinocytes in Hyperpigmented Spots Promote Melanocyte Activation via IGFBP3 and NGF. Int J Mol Sci. 2025;26(21):10724. Published 2025 Nov 4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sucrose dilaurate Related Classifications
HY-182824 Related Classifications
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