2. Autophagy
  3. Autophagy
  4. MPM-1

MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells.

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MPM-1 Chemical Structure

MPM-1 Chemical Structure

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MPM-1 Related Antibodies

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Description

MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells[1].

IC50 & Target

Autophagy[1]
In Vitro

MPM-1 (0-50 μM; 4 h) has cytotoxicity against various human cancer cell lines[1].
MPM-1 (8.5 and 17.0 μM; 1-6 h) causes perturbation of autophagy and lysosomal swelling[1].
MPM-1 induces the release and exposure of damage-associated molecular patterns (DAMPs) related to immunogenic cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MPM-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Jurkat, Ramos, HSC-3, MCF-7, A375, et al.
Concentration: 0-50 μM
Incubation Time: 4 h
Result: Exhibited potent cytotoxicity against Jurkat, Ramos, HSC-3, MCF-7, A375 with IC50s of 6.62 ± 1.60 μM, 7.53 ± 2.01 μM, 8.53 ± 0.57 μM, 14.06 ± 2.71 μM, 14.52 ± 0.22 μM, respectively.

Immunofluorescence[1]

Cell Line: HSC-3
Concentration: 8.5 and 17.0 μM
Incubation Time: 1, 2, 4 and 6 h
Result: Significantly increased the total number of autophagy markers p62 (substrate of autophagy) and LC3B.
Caused the distribution of the lysotracker dye more diffuse and less intense, indicating that lysosomal morphology was influenced.

Western Blot Analysis[1]

Cell Line: Ramos and HSC-3
Concentration: 8.5 μM for Romas and 17.0 μM for HSC-3
Incubation Time: 0.5, 1, 2, 3 and 4 h
Result: Increased the release of high mobility group box 1 (HMGB1) from cells.
Molecular Weight

734.73

Formula

C34H44F6N4O7
SMILES

NCCCCN1C(N(C(C(CCCC2=CC=CC=C2)(C1=O)CCCC3=CC=CC=C3)=O)CCCCN)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MPM-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPM-1MPM1MPM 1AutophagyEusynstyelamidesmimicanticancerimmunogeniclysosomal swellingDAMPsHSC-3RamosInhibitorinhibitorinhibit

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