MPM-1
MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells.
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- Formule: C34H44F6N4O7
- Masse moléculaire:734.73
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
Autophagy[1]
In Vitro
MPM-1 (0-50 μM; 4 h) has cytotoxicity against various human cancer cell lines[1].
MPM-1 (8.5 and 17.0 μM; 1-6 h) causes perturbation of autophagy and lysosomal swelling[1].
MPM-1 induces the release and exposure of damage-associated molecular patterns (DAMPs) related to immunogenic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat, Ramos, HSC-3, MCF-7, A375, et al.
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Concentration:0-50 μM
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Incubation Time:4 h
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Result:Exhibited potent cytotoxicity against Jurkat, Ramos, HSC-3, MCF-7, A375 with IC50s of 6.62 ± 1.60 μM, 7.53 ± 2.01 μM, 8.53 ± 0.57 μM, 14.06 ± 2.71 μM, 14.52 ± 0.22 μM, respectively.
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Cell Line:HSC-3
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Concentration:8.5 and 17.0 μM
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Incubation Time:1, 2, 4 and 6 h
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Result:Significantly increased the total number of autophagy markers p62 (substrate of autophagy) and LC3B.
Caused the distribution of the lysotracker dye more diffuse and less intense, indicating that lysosomal morphology was influenced.
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Cell Line:Ramos and HSC-3
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Concentration:8.5 μM for Romas and 17.0 μM for HSC-3
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Incubation Time:0.5, 1, 2, 3 and 4 h
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Result:Increased the release of high mobility group box 1 (HMGB1) from cells.
Chemical Information
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Masse moléculaire 734.73
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Formule C34H44F6N4O7
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SMILES
NCCCCN1C(N(C(C(CCCC2=CC=CC=C2)(C1=O)CCCC3=CC=CC=C3)=O)CCCCN)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPM-1 Related Classifications
HY-151503 Related Classifications
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