MPM-1
MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells.
For research use only. We do not sell to patients.
- Formula: C34H44F6N4O7
- Molecular Weight:734.73
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Autophagy[1]
MPM-1 (0-50 μM; 4 h) has cytotoxicity against various human cancer cell lines[1].
MPM-1 (8.5 and 17.0 μM; 1-6 h) causes perturbation of autophagy and lysosomal swelling[1].
MPM-1 induces the release and exposure of damage-associated molecular patterns (DAMPs) related to immunogenic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Jurkat, Ramos, HSC-3, MCF-7, A375, et al.
-
Concentration:0-50 μM
-
Incubation Time:4 h
-
Result:Exhibited potent cytotoxicity against Jurkat, Ramos, HSC-3, MCF-7, A375 with IC50s of 6.62 ± 1.60 μM, 7.53 ± 2.01 μM, 8.53 ± 0.57 μM, 14.06 ± 2.71 μM, 14.52 ± 0.22 μM, respectively.
-
Cell Line:HSC-3
-
Concentration:8.5 and 17.0 μM
-
Incubation Time:1, 2, 4 and 6 h
-
Result:Significantly increased the total number of autophagy markers p62 (substrate of autophagy) and LC3B.
Caused the distribution of the lysotracker dye more diffuse and less intense, indicating that lysosomal morphology was influenced.
-
Cell Line:Ramos and HSC-3
-
Concentration:8.5 μM for Romas and 17.0 μM for HSC-3
-
Incubation Time:0.5, 1, 2, 3 and 4 h
-
Result:Increased the release of high mobility group box 1 (HMGB1) from cells.
Chemical Information
-
Molecular Weight 734.73
-
Formula C34H44F6N4O7
-
SMILES
NCCCCN1C(N(C(C(CCCC2=CC=CC=C2)(C1=O)CCCC3=CC=CC=C3)=O)CCCCN)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPM-1 Related Classifications
HY-151503 Related Classifications
Powered by Bioz