2. PI3K/Akt/mTOR
  3. mTOR
  4. CC214-1

CC214-1 is a potentially efficacious mTOR inhibitor that induces autophagy ,with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study.

For research use only. We do not sell to patients.

CC214-1 Chemical Structure

CC214-1 Chemical Structure

CAS No. : 1021920-32-0

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CC214-1 Related Antibodies

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Description

CC214-1 is a potentially efficacious mTOR inhibitor that induces autophagy [1],with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study[2].

IC50 & Target [2]

mTOR

0.002 μM (IC50)

In Vitro

CC214-1 (0, 0.1, 1, 2, 5, 10 μM, 8 h; 2 μM, 24 h) synergize with rapamycin (HY-10219), inhibiting mTORC1 signaling and tumor cell proliferation[1].
CC214-1 (2 μM, 24 h) -mediated sensitivity to growth arrest in glioblastoma cells due to EGFRvIII expression and loss of PTEN[1].
CC214-1 (5 μM, 0-48 h) massively lipidates LC3B-I to LC3B-II subtype and induces autophagy in GBM39 cells[1].
CC214-1 has an IC50 of mTOR is 0.002 μM[2].
CC214-1 (0-10 μM, 4days) is efficient in inhibiting T cell activation and the expression of T-cell activation markers[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CC214-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: glioblastoma
Concentration: 0, 0.1, 1, 2, 5, 10 μM; 2 μM
Incubation Time: 8 h; 24 h
Result: Inhibited mTORC1 signaling in all glioblastoma cell lines tested, potently suppressing rapamycin-resistant 4E-BP1 and mTORC2 signaling.
Inhibited mTORC1-dependent 4E-BP1 and S6 phosphorylation in EGFRvIII-expressing glioblastoma cells, as well as blocked glioblastoma cells overexpressing wild-type EGFR.

Immunofluorescence[1]

Cell Line: glioblastoma
Concentration: 2 μM, 5 μM
Incubation Time: 4 h; 0, 4, 12, 24, 48 h
Result: Induced a transient expression of LC3B-II isoform and the conjugation of Atg12 to Atg5 indicative of the stimulation of the autophagy flux in U87EGFRvIII cell line.
Massively lipidated LC3B-I to LC3B-II subtype and induces autophagy in GBM39 cells.

Cell Cycle Analysis[3]

Cell Line: glioblastoma
Concentration: 0-10 μM
Incubation Time: 4 day
Result: Induced TEE cells in CD4+ and CD8+ T cell subsets.
Molecular Weight

391.43

Formula

C20H21N7O2
CAS No.
SMILES

O=C1NC2=NC=C(C3=CC=C(C4=NN=CN4)C=C3)N=C2N1CCC5CCOCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CC214-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CC214-11021920-32-0mTORMammalian target of RapamycinGlioblastomacardiovascularautophagyInhibitorinhibitorinhibit

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