1021920-32-0
1021920-32-0
Chemical Structure
CC214-1
- CAS No.: 1021920-32-0
- Formula:C20H21N7O2
- Molecular Weight:391.43
InChIKey: FFGUSRSMWFYKGK-UHFFFAOYSA-N
SMILES: O=C1NC2=NC=C(C3=CC=C(C4=NN=CN4)C=C3)N=C2N1CCC5CCOCC5
Biological Activity: CC214-1 is a potentially efficacious mTOR inhibitor that induces autophagy [1],with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study[2].
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CC214-1 | 98.49% | CC214-1 is a potentially efficacious mTOR inhibitor that induces autophagy ,with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study. | ||||||||||||||||||||
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References
- [1]. Gini B, et al. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15;19(20):5722-32. [Content Brief]
- [2]. Mortensen DS, et al. Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1588-91. [Content Brief]
Keywords
