2. Autophagy
  3. p62 Atg8/LC3 Autophagy
  4. XIE62-1004-A

XIE62-1004-A is an inducer of p62-LC3 interaction. XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent autophagy.

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XIE62-1004-A Chemical Structure

XIE62-1004-A Chemical Structure

CAS No. : 2421146-32-7

Size Price Stock Quantity
5 mg USD 110 In-stock
10 mg USD 170 In-stock
25 mg USD 330 In-stock
50 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

XIE62-1004-A Related Antibodies

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Description

XIE62-1004-A is an inducer of p62-LC3 interaction. XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent autophagy[1].

IC50 & Target

p62[1]
Molecular Weight

399.91

Formula

C23H26ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCCNCC1=CC=C(C(OCC2=CC=CC=C2)=C1)OCC3=CC=CC=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5006 mL 12.5028 mL 25.0056 mL
5 mM 0.5001 mL 2.5006 mL 5.0011 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5006 mL 12.5028 mL 25.0056 mL 62.5141 mL
5 mM 0.5001 mL 2.5006 mL 5.0011 mL 12.5028 mL
10 mM 0.2501 mL 1.2503 mL 2.5006 mL 6.2514 mL
15 mM 0.1667 mL 0.8335 mL 1.6670 mL 4.1676 mL
20 mM 0.1250 mL 0.6251 mL 1.2503 mL 3.1257 mL
25 mM 0.1000 mL 0.5001 mL 1.0002 mL 2.5006 mL
30 mM 0.0834 mL 0.4168 mL 0.8335 mL 2.0838 mL
40 mM 0.0625 mL 0.3126 mL 0.6251 mL 1.5629 mL
50 mM 0.0500 mL 0.2501 mL 0.5001 mL 1.2503 mL
60 mM 0.0417 mL 0.2084 mL 0.4168 mL 1.0419 mL
80 mM 0.0313 mL 0.1563 mL 0.3126 mL 0.7814 mL
100 mM 0.0250 mL 0.1250 mL 0.2501 mL 0.6251 mL
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XIE62-1004-A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XIE62-1004-A2421146-32-7p62Atg8/LC3AutophagySequestosome-1SQSTM1Autophagy-related 8| ZZ-domainautophagyLC3Inhibitorinhibitorinhibit

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