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Cat. No.: HY-146390

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Antiproliferative agent-5

Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer.

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CAS No.: 2459892-41-0
Formule: C₂₈H₂₁BrN₈OS
Masse moléculaire:597.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antiproliferative agent-5 Chemical Structure

CAS No.: 2459892-41-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

ROS, Autophagy^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	>10 μM Compound: 4o	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay	[PMID: 32683165]
BGC-823	GI₅₀	0.64 μM Compound: 4o	Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay	[PMID: 32683165]
EJ	GI₅₀	>10 μM Compound: 4o	Antiproliferative activity against human EJ cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay Antiproliferative activity against human EJ cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay	[PMID: 32683165]
HGC-27	GI₅₀	0.64 μM Compound: 4o	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay	[PMID: 32683165]
MGC-803	GI₅₀	0.64 μM Compound: 4o	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay	[PMID: 32683165]
MKN-45	GI₅₀	0.64 μM Compound: 4o	Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay	[PMID: 32683165]
SGC-7901	GI₅₀	0.64 μM Compound: 4o	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay	[PMID: 32683165]
SW-620	IC₅₀	0.058 μM Compound: 24	Reversal of resistance to paclitaxel-induced cytotoxicity in human SW-620/AD300 cells assessed as reduction in paclitaxel IC50 at 1 uM preincubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.50 uM) Reversal of resistance to paclitaxel-induced cytotoxicity in human SW-620/AD300 cells assessed as reduction in paclitaxel IC50 at 1 uM preincubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.50 uM)	[PMID: 34723530]

Chemical Information

CAS No. 2459892-41-0
Masse moléculaire 597.49
Formule C₂₈H₂₁BrN₈OS
SMILES

O=C(C1=CC=C(NC2=CC(C)=NC3=NC(SCC4=NC5=CC=CC=C5N4)=NN23)C=C1)/C=C/C6=NC(Br)=CC=C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang S, et al. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway. Eur J Med Chem. 2020;203:112630. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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