2. Autophagy
  3. Autophagy
  4. Euxanthone

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.

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Euxanthone Chemical Structure

Euxanthone Chemical Structure

CAS No. : 529-61-3

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Euxanthone Related Antibodies

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Description

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

In Vitro

Euxanthone (10-20 μM; 24 h) compromises the capability of OS cells to migrate in a dose-dependent fashion, and significantly suppresses cell invasion. Euxanthone presents a significant decrease in adhesion to fibronectin[1].
Euxanthone (10-20 μM; 24 h) modulates the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway. The repression of COX-2 by Euxanthone mediated its anti-metastatic activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Euxanthone Related Antibodies

Cell Migration Assay [1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Inhibited cell migration at 24 hr.

Western Blot Analysis[1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
In Vivo

Euxanthone (40-80 mg/kg) could significantly decrease the number of metastatic nodules in lung tissue in a pulmonary metastasis model[1].
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2]
Dosage: 30 mg/kg, 60 mg/kg
Administration: p.o.;once a day; for 7 days
Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
Molecular Weight

228.20

Formula

C13H8O4
CAS No.
SMILES

O=C1C2=C(OC3=C1C=C(O)C=C3)C=CC=C2O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Euxanthone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Euxanthone529-61-3Autophagyoxidative stressxanthoneanti-neoplastic and neuroprotective activitiesCOX-2anti-metastaticInhibitorinhibitorinhibit

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