Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy

  • J Mol Neurosci. 2018 Dec;66(4):512-523. doi: 10.1007/s12031-018-1175-2.
Haicheng Yuan  1 ,  Chuanwu Jiang  2  3 ,  Jingde Zhao  3 ,  Yunsheng Zhao  4 ,  Yongbin Zhang  3 ,  Yanqi Xu  3 ,  Xiaoning Gao  3 ,  Lingfei Guo  5 ,  Yongji Liu  6 ,  Kai Liu  2 ,  Bo Xu  7 ,  Gang Sun  8
Affiliations
  • 1. Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China.
  • 2. Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China.
  • 3. Department of Interventional Radiology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.
  • 4. Department of Endocrinology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.
  • 5. Department of Interventional Radiology, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
  • 6. Department of Neurosurgery, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.
  • 7. Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China. [email protected].
  • 8. Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China. [email protected].
PMID: 30345461 DOI: 10.1007/s12031-018-1175-2
Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ1-42-induced memory and spatial learning dysfunction and also significantly reversed Aβ1-42-induced neuronal Apoptosis and Autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ1-42-induced oxidative stress and Apoptosis by inducing Autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ1-42 by inducing Autophagy, indicating its potential therapeutic role in AD.

Keywords
Alzheimer’s disease; Autophagy; Euxanthone.
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