ADTL-SA1215
Based on 2 publication(s) in Google Scholar
ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.96%
- CAS No.: 782387-91-1
- Formula: C26H29I2NO3
- Molecular Weight:657.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Antioxidant Compound Library
HY-L037
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Oxygen Sensing Compound Library
HY-L045
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Glutamine Metabolism Compound Library
HY-L064
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Anti-Breast Cancer Compound Library
HY-L074
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Activators Library
HY-L159
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Radioprotector Library
HY-L178
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) ADTL-SA1215
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
2.8 μM
Compound: 33c
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Antiproliferative activity against human HL-60 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human HL-60 cells measured after 24 hrs by MTT assay
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[PMID: 34605238] |
| MCF7 | IC50 |
12.46 μM
Compound: 33c
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Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
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[PMID: 34605238] |
| MDA-MB-231 | IC50 |
2.19 μM
Compound: 33c
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Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay
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[PMID: 34605238] |
| MDA-MB-231 | IC50 |
2.19 μM
Compound: 17
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 38261767] |
| U-937 | IC50 |
2.52 μM
Compound: 33c
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Antiproliferative activity against human U-937 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human U-937 cells measured after 24 hrs by MTT assay
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[PMID: 34605238] |
Chemical Information
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CAS No. 782387-91-1
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Appearance Solid
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Molecular Weight 657.32
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Formula C26H29I2NO3
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Color Light brown to brown
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SMILES
O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCCN4CCCC4)C(I)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Environ Sci Technol
IodoFinder: Machine Learning-Guided Recognition of Iodinated Chemicals in Nontargeted LC-MS/MS Analysis. [Abstract]2025 Mar 11;59(9):4530-4539. PMID: 40015982 -
Int J Biol Sci
DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence. [Abstract]2026 Feb 4;22(5):2435-2451. PMID: 41800262
Solvent & Solubility
DMSO : 100 mg/mL (152.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 1.25 mg/mL (1.90 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.25 mg/mL (1.90 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5213 mL | 7.6066 mL | 15.2133 mL | 38.0332 mL |
| 5 mM | 0.3043 mL | 1.5213 mL | 3.0427 mL | 7.6066 mL | |
| 10 mM | 0.1521 mL | 0.7607 mL | 1.5213 mL | 3.8033 mL | |
| 15 mM | 0.1014 mL | 0.5071 mL | 1.0142 mL | 2.5355 mL | |
| 20 mM | 0.0761 mL | 0.3803 mL | 0.7607 mL | 1.9017 mL | |
| 25 mM | 0.0609 mL | 0.3043 mL | 0.6085 mL | 1.5213 mL | |
| 30 mM | 0.0507 mL | 0.2536 mL | 0.5071 mL | 1.2678 mL | |
| 40 mM | 0.0380 mL | 0.1902 mL | 0.3803 mL | 0.9508 mL | |
| 50 mM | 0.0304 mL | 0.1521 mL | 0.3043 mL | 0.7607 mL | |
| 60 mM | 0.0254 mL | 0.1268 mL | 0.2536 mL | 0.6339 mL | |
| 80 mM | 0.0190 mL | 0.0951 mL | 0.1902 mL | 0.4754 mL | |
| 100 mM | 0.0152 mL | 0.0761 mL | 0.1521 mL | 0.3803 mL |
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