2. Autophagy
  3. Autophagy
  4. 501A054

501A054 is an autophagy activator. 501A054 induces autophagy-dependent cell death via autophagy activation. 501A054 can be used in studies on autophagy regulation such as cervical cancer.

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501A054

501A054 Chemical Structure

CAS No. : 3080980-06-6

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Description

501A054 is an autophagy activator. 501A054 induces autophagy-dependent cell death via autophagy activation. 501A054 can be used in studies on autophagy regulation such as cervical cancer[1].

In Vitro

501A054 (Compound 3o) (4 h) potently activates autophagy in HeLa cells stably expressing eGFP-LC3, with an EC50 of 2.3 μM[1].
501A054 (16-32 μM; 4-24 h) induces autophagy-dependent perinuclear vacuole formation in eGFP-LC3 HeLa cells after treatment with 16 μM for 4 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

501A054 Related Antibodies

Immunofluorescence[1]

Cell Line: eGFP-LC3 HeLa cells, ATG9A KO HeLa cells
Concentration: 16 μM (eGFP-LC3 HeLa cells); 32 μM (ATG9A KO HeLa cells)
Incubation Time: 4 h (eGFP-LC3 HeLa cells); 24 h (ATG9A KO HeLa cells)
Result: Induced perinuclear vacuole formation in eGFP-LC3 HeLa cells at 16 μM after 4 h.
Showed no vacuole formation in ATG9A KO HeLa cells at 32 μM after 24 h.
Molecular Weight

433.59

Formula

C27H35N3O2
CAS No.
SMILES

OCC1CN(CCC2=CC=CC=C2)CC31CCN(CC4=CNC5=C4C=C(OC)C=C5)CC3
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References
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501A054 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

501A0543080980-06-6AutophagyAutophagy activatorHeLa cells
Inhibitorinhibitorinhibit

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