501A054
501A054 is an autophagy activator. 501A054 induces autophagy-dependent cell death via autophagy activation. 501A054 can be used in studies on autophagy regulation such as cervical cancer.
For research use only. We do not sell to patients.
- CAS No.: 3080980-06-6
- Formula: C27H35N3O2
- Molecular Weight:433.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
501A054 (Compound 3o) (4 h) potently activates autophagy in HeLa cells stably expressing eGFP-LC3, with an EC50 of 2.3 μM[1].
501A054 (16-32 μM; 4-24 h) induces autophagy-dependent perinuclear vacuole formation in eGFP-LC3 HeLa cells after treatment with 16 μM for 4 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:eGFP-LC3 HeLa cells, ATG9A KO HeLa cells
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Concentration:16 μM (eGFP-LC3 HeLa cells); 32 μM (ATG9A KO HeLa cells)
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Incubation Time:4 h (eGFP-LC3 HeLa cells); 24 h (ATG9A KO HeLa cells)
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Result:Induced perinuclear vacuole formation in eGFP-LC3 HeLa cells at 16 μM after 4 h.
Showed no vacuole formation in ATG9A KO HeLa cells at 32 μM after 24 h.
Chemical Information
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CAS No. 3080980-06-6
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Molecular Weight 433.59
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Formula C27H35N3O2
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SMILES
OCC1CN(CCC2=CC=CC=C2)CC31CCN(CC4=CNC5=C4C=C(OC)C=C5)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
501A054 Related Classifications
HY-181724 Related Classifications
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