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Cat. No.: HY-123056A

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EAD1 TFA

EAD1 TFA is a Chloroquine (HY-17589A) analog with anticancer activity. EAD1 TFA blocks autophagy, leading to the intracellular accumulation of autophagosome-related proteins LC3-II and p62. EAD1 TFA induces cancer cell apoptosis and inhibits cancer cell proliferation. EAD1 TFA can be used in the research of lung cancer and pancreatic cancer.

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CAS No.: 2320427-95-8
Formule: C₂₆H₂₈Cl₂F₃N₇O₂
Masse moléculaire:598.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EAD1 TFA Chemical Structure

CAS No.: 2320427-95-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

EAD1 (compound 3h) (72 h) TFA potently inhibits the proliferation of H460, HCC827 and BxPC3 cancer cells at 72 h, with IC₅₀ values of 11 μM, 7.6 μM and 5.8 μM, respectively^[1].
EAD1 (6.5-100 μM; 24 h) TFA potently inhibits colony formation of H460 non-small cell lung cancer cells^[1].
EAD1 (5-75 μM; 24 h) TFA induces concentration-dependent apoptosis in H460 non-small cell lung cancer (NSCLC) cells^[1].
EAD1 (25-50 μM; 6 h) TFA enhances the expression of punctate LC3 in H3122 non-small cell lung cancer cells^[1].
EAD1 (1-25 μM, 10 μM; 2-72 h, 24 h) TFA induces concentration- and time-dependent accumulation of autophagy-related proteins LC3-II and p62 in H460 non-small cell lung cancer (NSCLC) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2320427-95-8
Masse moléculaire 598.45
Formule C₂₆H₂₈Cl₂F₃N₇O₂
SMILES

O=C(C(F)(F)F)O.ClC1=CC=C(CN2N=NC(CNCCN(CCNC3=C4C=CC(Cl)=CC4=NC=C3)C)=C2)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lars Ulrik Nordstrøm, et al. Discovery of Autophagy Inhibitors With Antiproliferative Activity in Lung and Pancreatic Cancer Cells. ACS Med Chem Lett. 2015 Jan 8;6(2):134-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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