EAD1 TFA 

EAD1 TFA is a Chloroquine (HY-17589A) analog with anticancer activity. EAD1 TFA blocks autophagy, leading to the intracellular accumulation of autophagosome-related proteins LC3-II and p62. EAD1 TFA induces cancer cell apoptosis and inhibits cancer cell proliferation. EAD1 TFA can be used in the research of lung cancer and pancreatic cancer^[1].

EAD1 (compound 3h) (72 h) TFA potently inhibits the proliferation of H460, HCC827 and BxPC3 cancer cells at 72 h, with IC₅₀ values of 11 μM, 7.6 μM and 5.8 μM, respectively^[1].
EAD1 (6.5-100 μM; 24 h) TFA potently inhibits colony formation of H460 non-small cell lung cancer cells^[1].
EAD1 (5-75 μM; 24 h) TFA induces concentration-dependent apoptosis in H460 non-small cell lung cancer (NSCLC) cells^[1].
EAD1 (25-50 μM; 6 h) TFA enhances the expression of punctate LC3 in H3122 non-small cell lung cancer cells^[1].
EAD1 (1-25 μM, 10 μM; 2-72 h, 24 h) TFA induces concentration- and time-dependent accumulation of autophagy-related proteins LC3-II and p62 in H460 non-small cell lung cancer (NSCLC) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

598.45

C₂₆H₂₈Cl₂F₃N₇O₂

2320427-95-8

O=C(C(F)(F)F)O.ClC1=CC=C(CN2N=NC(CNCCN(CCNC3=C4C=CC(Cl)=CC4=NC=C3)C)=C2)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lars Ulrik Nordstrøm, et al. Discovery of Autophagy Inhibitors With Antiproliferative Activity in Lung and Pancreatic Cancer Cells. ACS Med Chem Lett. 2015 Jan 8;6(2):134-9.  [Content Brief]