2. Autophagy Apoptosis
  3. Autophagy Apoptosis
  4. EAD1

EAD1 is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 also induces apoptosis.

For research use only. We do not sell to patients.

EAD1 Chemical Structure

EAD1 Chemical Structure

CAS No. : 1644388-26-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

EAD1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EAD1 is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 also induces apoptosis[1].

In Vitro

EAD1 (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines[1].
EAD1 (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner[1].
EAD1 (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EAD1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: H460 and HCC827 nonsmall cell lung cancer (NSCLC) and BxPC3 pancreatic cancer cells
Concentration: 0, 50, 100, 150, 200 μM
Incubation Time: 72 hours
Result: IC50s of 11, 7.6, and 5.8 μM for H460, HCC827, and BxPC3 cells, respectively.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 5, 25, 50, and 75 μM
Incubation Time: 24 hours
Result: Induction of apoptosis.

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1, 2.5, 5, 10, 25 μM
Incubation Time: 24 hours
Result: Caused concentration and time-dependent increases in LC3-II levels.
Molecular Weight

484.42

Formula

C24H27Cl2N7
CAS No.
SMILES

CN(CCNCC1=CN(CC2=CC=C(Cl)C=C2)N=N1)CCNC3=CC=NC4=CC(Cl)=CC=C34
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

EAD1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EAD11644388-26-0EAD 1EAD-1AutophagyApoptosisantiproliferativelungpancreaticcancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
EAD1
Cat. No.:
HY-123056
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.