1. Autophagy
    Apoptosis
  2. Autophagy
    Apoptosis
  3. EAD1

EAD1 

Cat. No.: HY-123056
Handling Instructions

EAD1 is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 also induces apoptosis.

For research use only. We do not sell to patients.

EAD1 Chemical Structure

EAD1 Chemical Structure

CAS No. : 1644388-26-0

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Description

EAD1 is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 also induces apoptosis[1].

In Vitro

EAD1 (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines[1].
EAD1 (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner[1].
EAD1 (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells[1].

Cell Proliferation Assay[1]

Cell Line: H460 and HCC827 nonsmall cell lung cancer (NSCLC) and BxPC3 pancreatic cancer cells
Concentration: 0, 50, 100, 150, 200 μM
Incubation Time: 72 hours
Result: IC50s of 11, 7.6, and 5.8 μM for H460, HCC827, and BxPC3 cells, respectively.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 5, 25, 50, and 75 μM
Incubation Time: 24 hours
Result: Induction of apoptosis.

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1, 2.5, 5, 10, 25 μM
Incubation Time: 24 hours
Result: Caused concentration and time-dependent increases in LC3-II levels.
Molecular Weight

484.42

Formula

C₂₄H₂₇Cl₂N₇

CAS No.

1644388-26-0

SMILES

CN(CCNCC1=CN(CC2=CC=C(Cl)C=C2)N=N1)CCNC3=CC=NC4=CC(Cl)=CC=C34

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

EAD1EAD 1EAD-1AutophagyApoptosisantiproliferativelungpancreaticcancerInhibitorinhibitorinhibit

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