1. Autophagy
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  3. QX77

QX77 

Cat. No.: HY-112483 Purity: 99.44%
Handling Instructions

QX77 is a chaperone-mediated autophagy (CMA) activator.

For research use only. We do not sell to patients.

QX77 Chemical Structure

QX77 Chemical Structure

CAS No. : 1798331-92-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

QX77 is a chaperone-mediated autophagy (CMA) activator.

IC50 & Target

CMA[1]

In Vitro

Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane[1].

Molecular Weight

300.74

Formula

C₁₆H₁₃ClN₂O₂

CAS No.

1798331-92-6

SMILES

CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 64 mg/mL (212.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3251 mL 16.6257 mL 33.2513 mL
5 mM 0.6650 mL 3.3251 mL 6.6503 mL
10 mM 0.3325 mL 1.6626 mL 3.3251 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Mouse embryo fibroblasts are preincubated with QX77 or vehicle (DMSO) 48 h before the addition of tert-butyl hydroperoxide. After an overnight incubation, cell viability is determined by a modified version of the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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QX77
Cat. No.:
HY-112483
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