1798331-92-6
1798331-92-6
Chemical Structure
QX77
- CAS No.: 1798331-92-6
- Formula:C16H13ClN2O2
- Molecular Weight:300.74
IUPAC Name: N-(4-(7-chloro-2H-benzo[b][1,4]oxazin-3-yl)phenyl)acetamide
InChIKey: PYCTUCLCTVWILY-UHFFFAOYSA-N
SMILES: CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O
Biological Activity: QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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QX77 | 99.48% | QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 can impede self-renewal and promote differentiation of ES cells. | ||||||||||||||||||||
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References
- [1]. Jinzhong Zhang, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346 [Content Brief]
- [2]. Yi Xu, et al. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369(6502):397-403. [Content Brief]
