2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis Autophagy
  3. HSP Apoptosis Autophagy
  4. JD-02

JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species.

For research use only. We do not sell to patients.

JD-02 Chemical Structure

JD-02 Chemical Structure

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JD-02 Related Antibodies

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Description

JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species[1].

In Vitro

JD-02 (0–2  μM, 24, 48, and 72  h) inhibits growth and in HTC116 and SW620 cells[1].
JD-02 (1  μM, 36 h) induces G0/G1 phase arrest in HTC116 and SW620 cells[1].
JD-02 (1  μM, 48  h) induces cell apoptosis in HTC116 and SW620 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JD-02 Related Antibodies

Cell Viability Assay[1]

Cell Line: HTC116 and SW620 cells
Concentration: 0–2  μM
Incubation Time: 24, 48, and 72  h
Result: Inhibited cell growth.

Apoptosis Analysis[1]

Cell Line: HTC116 and SW620 cells
Concentration: 1  μM
Incubation Time: 48 h.
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: HTC116 and SW620 cells
Concentration: 1  μM
Incubation Time: 36 h
Result: Induced G0/G1 phase arrest.
In Vivo

JD-02 (5, 10, and 20 mg/kg for i.p; 21 days) decreases tumor development in HCT116 cell xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 cell xenograft mouse model[1]
Dosage: 5, 10, and 20 mg/kg
Administration: Intravenous injection for 21 days
Result: decreased tumor development by 64.3%.
Molecular Weight

424.54

Formula

C23H32N6O2
SMILES

CC1=NN(C2=CC=C(C(N)=O)C(N[C@@H]3CC[C@@H](O)CC3)=C2)C4=C1/C(CC(C)(C)C4)=N/N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JD-02 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JD-02JD02JD 02HSPApoptosisAutophagyHeat shock proteinscolorectal cancerreactive oxygen speciesautophagyapoptosisInhibitorinhibitorinhibit

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