2. Autophagy
  3. Autophagy
  4. Forigerimod

Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .

For research use only. We do not sell to patients.

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Forigerimod Chemical Structure

Forigerimod Chemical Structure

CAS No. : 497156-60-2

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Description

Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) [1][2][3][4].

In Vivo

Forigerimod (P140) (i.v.; 100 μg in 100 μL saline per mouse) directly acts on chaperone-mediated autophagy, rescues MRL/lpr mice from cellular infiltration and autophagy defects occurring in salivary glands[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRL/lpr mice[4]
Dosage: 100 μg in 100 μL saline per mouse
Administration: Intravenous administration, single
Result: Corrected the cell content and distribution in MRL/lpr salivary glands.
Corrected the defective of autophagy processes in SGs of MRL/lpr mice.
Molecular Weight

2638.94

Formula

C117H181N34O32PS
CAS No.
Sequence

Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-{pSer}-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr
Sequence Shortening

RIHMVYSKR-{pSer}-GKPRGYAFIEY
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Forigerimod Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Forigerimod497156-60-2IPP-201101IPP201101IPP 201101AutophagyCD4 T-cellU1 small nuclear ribonucleoproteinSer140autophagyautoimmune disorderssystemic lupus erythematosus (SLE)Inhibitorinhibitorinhibit

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