2. Autophagy
  3. Autophagy
  4. Forigerimod TFA

Forigerimod TFA  (Synonyms: IPP-201101 TFA)

Cat. No.: HY-105037A Purity: 98.89%
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Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .

For research use only. We do not sell to patients.

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Forigerimod TFA Chemical Structure

Forigerimod TFA Chemical Structure

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5 mg USD 520 In-stock
10 mg USD 830 In-stock
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Based on 1 publication(s) in Google Scholar

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Forigerimod TFA Related Antibodies

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Description

Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) [1][2][3][4].

In Vivo

Forigerimod TFA (P140) (i.v.; 100 μg in 100 μL saline per mouse) directly acts on chaperone-mediated autophagy, rescues MRL/lpr mice from cellular infiltration and autophagy defects occurring in salivary glands[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRL/lpr mice[4]
Dosage: 100 μg in 100 μL saline per mouse
Administration: Intravenous administration, single
Result: Corrected the cell content and distribution in MRL/lpr salivary glands.
Corrected the defective of autophagy processes in SGs of MRL/lpr mice.
Formula

C117H181N34O32PS.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence Shortening

RIHMVYSKR-{pSer}-GKPRGYAFIEY (TFA)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.89%

COA (242 KB) RP-HPLC (110 KB) MS (219 KB)

Handling Instructions (2659 KB)
References
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Forigerimod TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ForigerimodIPP-201101IPP201101IPP 201101AutophagyCD4 T-cellU1 small nuclear ribonucleoproteinSer140autophagyautoimmune disorderssystemic lupus erythematosus (SLE)Inhibitorinhibitorinhibit

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