Olaparib-d₄-2  (Synonyms: AZD2281-d₄-2; KU0059436-d₄-2)

Olaparib-d₄-2 is the deuterium labeled Olaparib (HY-10162). Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC₅₀s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator. Olaparib cannot cross the intact blood-brain barrier (BBB)^{[1][2][3][4][5][6]}.

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

438.49

C₂₄H₁₉D₄FN₄O₃

763113-22-0

O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(C4([2H])C([2H])([2H])C4[2H])=O)CC3)=O)=C2)C5=C1C=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.