2. NF-κB Autophagy
  3. IKK Autophagy
  4. IKKε-IN-1

IKKε-IN-1 is a IKKε inhibitor. IKKε-IN-1 reduces cell viability, inhibits colony formation and cell migration. IKKε-IN-1 induces autophagy (Autophagy) in cancer cells. IKKε-IN-1 can be used in the research of cancers including colorectal cancer, hepatocellular carcinoma, bladder cancer, breast cancer, lung cancer, and cervical cancer.

For research use only. We do not sell to patients.

IKKε-IN-1

IKKε-IN-1 Chemical Structure

CAS No. : 3035441-37-0

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IKKε-IN-1 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

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Description

IKKε-IN-1 is a IKKε inhibitor. IKKε-IN-1 reduces cell viability, inhibits colony formation and cell migration. IKKε-IN-1 induces autophagy (Autophagy) in cancer cells. IKKε-IN-1 can be used in the research of cancers including colorectal cancer, hepatocellular carcinoma, bladder cancer, breast cancer, lung cancer, and cervical cancer[1].

IC50 & Target

IKKε

 

In Vitro

IKKε-IN-1 (6.25-50 μM; 72 h) reduces the viability of HCT116, HepG2, T24, MDA-MB-231, A549 and Hela cells, with the strongest activity against HCT116 colorectal cancer cells (IC50 = 13.37 μM)[1].
IKKε-IN-1 (6.25-50 μM; 2-14 days) inhibits the long-term proliferation of HCT116 and HepG2 cells, and reduces the migration of HCT116 cells[1].
IKKε-IN-1 (12.5-50 μM; 48 h) induces autophagosome formation but blocks autophagic flux in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IKKε-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HCT116、HepG2、T24、MDA-MB-231、A549、Hela cells
Concentration: 6.25、12.5、25、50 μM
Incubation Time: 72 h
Result: Reduced cell viability in all six cancer cell lines in a concentration-dependent manner.
Exhibited IC50 values of 13.37 μM (HCT116), 17.44 μM (HepG2), 29.733 μM (T24), 32.48 μM (MDA-MB-231), 66.3 μM (A549), and 68.05 μM (HeLa).

Cell Proliferation Assay[1]

Cell Line: HCT116, HepG2 cells
Concentration: 12.5、25、50 μM
Incubation Time: 14 days
Result: Reduced colony formation in both cell lines in a concentration-dependent manner.

Cell Migration Assay [1]

Cell Line: HCT116 cells
Concentration: 6.25、12.5 μM
Incubation Time: 48 h
Result: Inhibited the migration, had a more pronounced effect on reducing
cell migration at 12.5 μM.

Cell Autophagy Assay[1]

Cell Line: HCT116 cells
Concentration: 12.5、25、50 μM
Incubation Time: 48 h
Result: Increased the LC3B-II/LC3B-I ratio in a concentration-dependent manner, indicating increased autophagosome formation, and also increased p62 levels in a concentration-dependent manner, indicating blocked autophagic flux.
Significantly increased the number of yellow autophagosome puncta, confirming impaired fusion of autophagosomes and lysosomes.
Molecular Weight

416.51

Formula

C26H28N2O3
CAS No.
SMILES

[H][C@]12CCCCN1CCC[C@H]2CNC(C3=CC=CC(C4=CC5=CC=CC=C5OC4=O)=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IKKε-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKKε-IN-13035441-37-0IKKAutophagyIκB kinaseI kappa B kinaseIKKε inhibitorcolorectal cancerhepatocellular carcinomabladder cancerbreast cancerlung cancercervical cancerInhibitorinhibitorinhibit

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