Curcumin 5-8
Based on 1 Customer Validation
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity.
For research use only. We do not sell to patients.
- Purity: 98.58%
- CAS No.: 890984-26-6
- Formula: C20H21NO4
- Molecular Weight:339.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Autophagy Compound Library
HY-L029
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Orally Active Compound Library
HY-L061
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Cell Death Library
HY-L162
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Anti-Drug-Resistant Compound Library
HY-L169
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
1.09 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against B16 cell line
Inhibitory concentration for cytotoxic activity against B16 cell line
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[PMID: 15993583] |
| HUVEC | IC50 |
1.44 μg/mL
Compound: Entry 8
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Inhibitory concentration against human umbilical vein endothelial cells(HUVEC) growth
Inhibitory concentration against human umbilical vein endothelial cells(HUVEC) growth
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[PMID: 15993583] |
| SiHa | IC50 |
5.96 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against SiHa cell line
Inhibitory concentration for cytotoxic activity against SiHa cell line
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[PMID: 15993583] |
| U-87MG ATCC | IC50 |
8.31 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against U87 cell line
Inhibitory concentration for cytotoxic activity against U87 cell line
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[PMID: 15993583] |
| Vero | IC50 |
3.47 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against Vero cell line
Inhibitory concentration for cytotoxic activity against Vero cell line
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[PMID: 15993583] |
Curcumin 5-8 (20 µM; 24 h) decreases PA (palmitic acid (HY-N0830))-induced SREBP1 expression levels and increases Bcl2/BAX expression in AML12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AML12 cells
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Concentration:20 µM
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Incubation Time:24 h
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Result:Significantly decreased PA-induced SREBP1 expression levels, increased Bcl2/BAX expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old males, 20 g, C57BL/6 mice[1]
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Dosage:100 mg/kg
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Administration:Diet; daily for 13 weeks
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Result:Significantly suppressed the increases in the insulin level and HOMA-IR.
Chemical Information
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CAS No. 890984-26-6
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Appearance Solid
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Molecular Weight 339.39
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Formula C20H21NO4
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Color Light yellow to yellow
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SMILES
O=C(C1=CC(NC(C(C)C)=O)=CC=C1)/C=C/C2=CC=C(C(OC)=C2)O
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Synonyms
CUR5-8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (294.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9465 mL | 14.7323 mL | 29.4646 mL | 73.6616 mL |
| 5 mM | 0.5893 mL | 2.9465 mL | 5.8929 mL | 14.7323 mL | |
| 10 mM | 0.2946 mL | 1.4732 mL | 2.9465 mL | 7.3662 mL | |
| 15 mM | 0.1964 mL | 0.9822 mL | 1.9643 mL | 4.9108 mL | |
| 20 mM | 0.1473 mL | 0.7366 mL | 1.4732 mL | 3.6831 mL | |
| 25 mM | 0.1179 mL | 0.5893 mL | 1.1786 mL | 2.9465 mL | |
| 30 mM | 0.0982 mL | 0.4911 mL | 0.9822 mL | 2.4554 mL | |
| 40 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8415 mL | |
| 50 mM | 0.0589 mL | 0.2946 mL | 0.5893 mL | 1.4732 mL | |
| 60 mM | 0.0491 mL | 0.2455 mL | 0.4911 mL | 1.2277 mL | |
| 80 mM | 0.0368 mL | 0.1842 mL | 0.3683 mL | 0.9208 mL | |
| 100 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7366 mL |
Curcumin 5-8 Related Classifications
HY-148598 Related Classifications
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