2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Curcumin 5-8

Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity.

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Curcumin 5-8 Chemical Structure

Curcumin 5-8 Chemical Structure

CAS No. : 890984-26-6

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Curcumin 5-8 Related Antibodies

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Description

Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity[1].

In Vitro

Curcumin 5-8 (20 µM; 24 h) decreases PA (palmitic acid (HY-N0830))-induced SREBP1 expression levels and increases Bcl2/BAX expression in AML12 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Curcumin 5-8 Related Antibodies

Western Blot Analysis[1]

Cell Line: AML12 cells
Concentration: 20 µM
Incubation Time: 24 h
Result: Significantly decreased PA-induced SREBP1 expression levels, increased Bcl2/BAX expression.
In Vivo

urcumin 5-8 (100 mg/kg; diet; daily for 13 weeks) ameliorates insulin resistance and hepatic steatosis in mice with HFD (high-fat diet)-induced obesity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old males, 20 g, C57BL/6 mice[1]
Dosage: 100 mg/kg
Administration: Diet; daily for 13 weeks
Result: Significantly suppressed the increases in the insulin level and HOMA-IR.
Molecular Weight

339.39

Formula

C20H21NO4
CAS No.
SMILES

O=C(C1=CC(NC(C(C)C)=O)=CC=C1)/C=C/C2=CC=C(C(OC)=C2)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Curcumin 5-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Curcumin 5-8890984-26-6CUR5-8ApoptosisAutophagyautophagyapoptosislipid dropletSREBP1AML12 cellsinsulin resistanceorally activeInhibitorinhibitorinhibit

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