Synthesis of novel curcumin mimics with asymmetrical units and their anti-angiogenic activity

  • Bioorg Med Chem Lett. 2005 Aug 15;15(16):3782-6. doi: 10.1016/j.bmcl.2005.05.064.
Ho Bum Woo  1 ,  Woon-Seob Shin ,  Seokjoon Lee ,  Chan Mug Ahn
Affiliations
  • 1. Department of Basic Sciences, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea.
PMID: 15993583 DOI: 10.1016/j.bmcl.2005.05.064
Abstract

Novel curcumin mimics with asymmetrical units phenyl group with alkyl amide, chloro-substituted benzamide, or heteroaromatic amide moieties were synthesized and their anti-angiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells. Compounds 5, 14, 17, and 18 showed potent growth inhibitory activity and tube formation inhibitory activity.