2. Metabolic Enzyme/Protease Others Apoptosis Immunology/Inflammation NF-κB Autophagy
  3. Herbicide Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Autophagy
  4. Prometryn

Prometryn is a triazine herbicide. Prometryn induces apoptosis and cell cycle arrest. Prometryn induces oxidative stress, DNA damage and autophagy-related gene expression, and non-specific immunity gene expression. Prometryn can be used for the research of herbicide, hepatopancreas injury, and intestinal stress and intestinal barrier dysfunction.

For research use only. We do not sell to patients.

Prometryn

Prometryn Chemical Structure

CAS No. : 7287-19-6

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Prometryn:

Prometryn Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Prometryn

  • Biological Activity

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  • References

  • Customer Review

Description

Prometryn is a triazine herbicide. Prometryn induces apoptosis and cell cycle arrest. Prometryn induces oxidative stress, DNA damage and autophagy-related gene expression, and non-specific immunity gene expression. Prometryn can be used for the research of herbicide, hepatopancreas injury, and intestinal stress and intestinal barrier dysfunction[1][2][3][4].

In Vitro

Prometryn (25-200 μM; 24-48 h) decreases the viability of BEAS-2B cells in a time- and concentration-dependent manner[1].
Prometryn (25-200 μM; 24-48 h) induces S phase cell cycle arrest in BEAS-2B cells at concentrations of 100 and 200 μM after 48 h of exposure, accompanied by reduced cyclin A and CDK2 expression and increased p53 expression[1].
Prometryn (25-200 μM; 48 h) induces apoptosis in BEAS-2B cells in a concentration-dependent manner at 100 and 200 μM after 48 h of exposure, mediated by altered expression of Bcl2, Bax, Caspase 9, Caspase 3, and PARP[1].
Prometryn (25-200 μM; 48 h) induces dose-dependent intracellular ROS generation in BEAS-2B cells, with significant increases detected at 200 μM after 48 h of exposure[1].
Prometryn (25-200 μM; 48 h) induces dose-dependent DNA damage in BEAS-2B cells[1].
Prometryn (5-20 mg/L; 96 hours) induces dose-dependent developmental toxicity in Danio rerio embryos over 96 hours, causing morphological defects, organogenesis failure, oxidative stress, apoptosis, and mitochondrial dysfunction, with an LC50 value of 23.14 mg/L[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Prometryn Related Antibodies

Cell Viability Assay[1]

Cell Line: human bronchial epithelial BEAS-2B cells
Concentration: 25 μM; 50 μM; 100 μM; 200 μM
Incubation Time: 24 h; 48 h
Result: Decreased BEAS-2B cell viability significantly at 100-200 μM after 48 h incubation (P < 0.01).
Showed no significant viability reduction after 24 h of treatment at any tested concentration.
Induced morphological changes including reduced cell volume, rounded cell shape, loss of intercellular connections, floating cells, and cell debris in cells treated with 50-200 μM for 48 h.

Cell Cycle Analysis[1]

Cell Line: human bronchial epithelial BEAS-2B cells
Concentration: 25 μM; 50 μM; 100 μM; 200 μM
Incubation Time: 24 h; 48 h
Result: Decreased the proportion of BEAS-2B cells in the G1 phase and increased the proportion in the S phase at 100 and 200 μM after 48 h incubation (P < 0.05), indicating S phase cell cycle arrest.
Reduced cyclin A and CDK2 protein expression in a dose-dependent manner via western blotting.
Increased p53 protein expression in a dose-dependent manner via western blotting.
Showed no cell cycle effects after 24 h of treatment at any concentration.

Apoptosis Analysis[1]

Cell Line: human bronchial epithelial BEAS-2B cells
Concentration: 25 μM; 50 μM; 100 μM; 200 μM
Incubation Time: 48 h
Result: Induced apoptosis in BEAS-2B cells at 100 μM with an apoptotic rate of ~6.5% (P < 0.01).
Induced apoptosis in BEAS-2B cells at 200 μM with an apoptotic rate of ~9% (P < 0.001).
Reduced anti-apoptotic Bcl2 protein expression in a dose-dependent manner via western blotting.
Increased pro-apoptotic Bax protein expression in a dose-dependent manner via western blotting.
Reduced expression of full-length Caspase 9, Caspase 3, and PARP via western blotting.
Increased expression of cleaved, active forms of Caspase 9, Caspase 3, and PARP via western blotting.
Molecular Weight

241.36

Formula

C10H19N5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CSC1=NC(NC(C)C)=NC(NC(C)C)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (414.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1432 mL 20.7159 mL 41.4319 mL
5 mM 0.8286 mL 4.1432 mL 8.2864 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1432 mL 20.7159 mL 41.4319 mL 103.5797 mL
5 mM 0.8286 mL 4.1432 mL 8.2864 mL 20.7159 mL
10 mM 0.4143 mL 2.0716 mL 4.1432 mL 10.3580 mL
15 mM 0.2762 mL 1.3811 mL 2.7621 mL 6.9053 mL
20 mM 0.2072 mL 1.0358 mL 2.0716 mL 5.1790 mL
25 mM 0.1657 mL 0.8286 mL 1.6573 mL 4.1432 mL
30 mM 0.1381 mL 0.6905 mL 1.3811 mL 3.4527 mL
40 mM 0.1036 mL 0.5179 mL 1.0358 mL 2.5895 mL
50 mM 0.0829 mL 0.4143 mL 0.8286 mL 2.0716 mL
60 mM 0.0691 mL 0.3453 mL 0.6905 mL 1.7263 mL
80 mM 0.0518 mL 0.2589 mL 0.5179 mL 1.2947 mL
100 mM 0.0414 mL 0.2072 mL 0.4143 mL 1.0358 mL
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Prometryn Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prometryn7287-19-6HerbicideEnvironmental PollutantsApoptosisReactive Oxygen Species (ROS)AutophagyEnvironmental ContaminantsCDK2PI3KBaxCyclin Ap53Bcl-2Aktzebrafish embryosEriocheir sinensisBEAS-2B cellsherbicideInhibitorinhibitorinhibit

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