2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-79

EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model.

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EGFR-IN-79

EGFR-IN-79 Chemical Structure

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EGFR-IN-79 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
15.1 μM
Compound: 21
Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
HT-1080 IC50
13 μM
Compound: 21
Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
MCF7 IC50
8.8 μM
Compound: 21
Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
NHDF IC50
39.7 μM
Compound: 21
Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
SW-620 IC50
10 μM
Compound: 21
Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
Molecular Weight

417.84

Formula

C23H16ClN3O3
SMILES

ClC1=CC=C(O)C(C2=CC(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NN2C4=CC=CC=C4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-79 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-79EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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EGFR-IN-79
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HY-155074
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