EGFR-IN-79
EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model.
For research use only. We do not sell to patients.
- CAS No.: 3049072-04-7
- Formula: C23H16ClN3O3
- Molecular Weight:417.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
15.1 μM
Compound: 21
|
Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 37098306] |
| HT-1080 | IC50 |
13 μM
Compound: 21
|
Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 37098306] |
| MCF7 | IC50 |
8.8 μM
Compound: 21
|
Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 37098306] |
| NHDF | IC50 |
39.7 μM
Compound: 21
|
Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 37098306] |
| SW-620 | IC50 |
10 μM
Compound: 21
|
Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 37098306] |
Chemical Information
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CAS No. 3049072-04-7
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Molecular Weight 417.84
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Formula C23H16ClN3O3
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SMILES
ClC1=CC=C(O)C(C2=CC(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NN2C4=CC=CC=C4)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)