3049072-04-7
3049072-04-7
Chemical Structure
EGFR-IN-79
- CAS No.: 3049072-04-7
- Formula:C23H16ClN3O3
- Molecular Weight:417.84
InChIKey: UJJZXPWQJRLHCP-PKNBQFBNSA-N
SMILES: ClC1=CC=C(O)C(C2=CC(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NN2C4=CC=CC=C4)=C1
Biological Activity: EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model[1].
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EGFR-IN-79 | EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model. | |||||||||||||||||||||
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