1. Autophagy
  2. Autophagy
  3. 4,4'-Dimethoxychalcone

4,4'-Dimethoxychalcone 

Cat. No.: HY-136064 Purity: >98.0%
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4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties.

For research use only. We do not sell to patients.

4,4'-Dimethoxychalcone Chemical Structure

4,4'-Dimethoxychalcone Chemical Structure

CAS No. : 2373-89-9

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Description

4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties[1].

IC50 & Target

Autophagy[1]

In Vivo

The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species[1].
4,4'-Dimethoxychalcone (100 mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice[1].

Animal Model: 6-week-old male wild type C57BL/6 or Atg4b-/- mice[1]
Dosage: 100 mg/kg
Administration: Injected intraperitoneally with a single
Result: Triggered autophagic flux in the heart and liver.
Molecular Weight

268.31

Formula

C₁₇H₁₆O₃

CAS No.

2373-89-9

SMILES

O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=C(OC)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (931.76 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7270 mL 18.6352 mL 37.2703 mL
5 mM 0.7454 mL 3.7270 mL 7.4541 mL
10 mM 0.3727 mL 1.8635 mL 3.7270 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (23.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (23.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

4,4'-DimethoxychalconeAutophagynaturalautophagyanti-ageingInhibitorinhibitorinhibit

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Product name:
4,4'-Dimethoxychalcone
Cat. No.:
HY-136064
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