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Y-27632 hydrochloride hydrate

429 Cited Publications
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Based on 429 publication(s) in Google Scholar

Y-27632 hydrochloride hydrate is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade.

For research use only. We do not sell to patients.

  • Purity: 99.65%
  • CAS No.: 331752-47-7
  • Formula: C14H25Cl2N3O2
  • Molecular Weight:338.27
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Y-27632 hydrochloride hydrate Chemical Structure
    Y-27632 hydrochloride hydrate Chemical Structure
  • Experimental Validation Results for Y-27632 hydrochloride hydrate
  • Experimental Validation Results for Y-27632 hydrochloride hydrate
  • Experimental Validation Results for Y-27632 hydrochloride hydrate
  • Experimental Validation Results for Y-27632 hydrochloride hydrate
CAS No.: 331752-47-7
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Histological Imaging/StainingWBIF
  • Histological Imaging/Staining
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  • Y-27632 hydrochloride hydrate Chemical Structure
    Y-27632 hydrochloride hydrate Chemical Structure
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    Y-27632 hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Jun 10;42(6):1086-1105.e13. [Abstract]

    Customer Validation
     Y-27632 (GBCs; 10 uM). Representative H&E of primary RPM tumor (top) vs GBC-derived RPM allograft (bottom) 。All scale bars, 50 μm. 

  • 1/16

    Y-27632 hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]

    Customer Validation
     Fluorescence imaging of LNCaP cells treated with the F-actin inhibitor cytoskeleton B (CB), microtubule inhibitor nocodazole (NO), FAK inhibitor PF573288 (PF), ROCK inhibitor Y-27632 (Y), and myosin II (Myo-II) inhibitor (-)-blebbistatin ((-)Bl). After the cells were cultured on different substrates for 3 days, inhibitors were added and incubated for 24 h. (green, F-actin; scale bar, 25 µm).

  • 1/16

    Y-27632 hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]

    Customer Validation
     Expression of CTC cluster-related (plakoglobin and CD44) and EMT-related (vimentin and E-cadherin, 4 days) proteins in LNCaP cells grown on different substrates after treatment with different inhibitors (Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl)).

  • 1/16

    Y-27632 hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 31;8(47):82506-82530. [Abstract]

    Customer Validation
     SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) cells were either untreated (-) or treated (+) with 10mM Y27632 over a period of 48 hr. SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) clones were either untreated (-) or treated (+) with 10 mM Y27632 followed by stimulation without (-) or with (+) 5 ng/mL of TGFβ1 for 48 hr.

  • Y-27632 hydrochloride hydrate