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Art. -Nr.: HY-162310

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Anticancer agent 193

Anticancer agent 193 (compound D3-3) is an inducer of ferritinophagy, eventually triggering ferroptosis. Anticancer agent 193 induces the production of lipid ROS, and significantly promoted colorectal cancer cells to release the ferrous ion in an autophagy-dependent manner.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₄H₄₇ClN₂O₆
Molecular Weight:615.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 193 Chemical Structure

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	11.18 μM Compound: D3-3	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay	[PMID: 38417218]
HCT-116	IC₅₀	15.06 μM Compound: D3-3	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 12 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 12 hrs by CCK-8 assay	[PMID: 38417218]
HCT-116	IC₅₀	5.87 μM Compound: D3-3	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 38417218]
HT-29	IC₅₀	6.71 μM Compound: D3-3	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 38417218]
NCM460	IC₅₀	19.04 μM Compound: D3-3	Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 38417218]

In Vitro

Anticancer agent 193 (D3-3; 2.5-30 μM; 12-48 h) inhibits the proliferation of HCT-116 cells for 12, 24, and 48 h and the IC₅₀ values are 15.06 μM, 11.18 μM, and 5.87 μM, respectively^[1].
Anticancer agent 193 (D3-3; 5-20 μM; 12 h) considerably increases the autophagy marker protein LC3B-II/LC3B-I ratio. And it enhances FTH1 expression, a ferritin subunit^[1].
Anticancer agent 193 (D3-3; 5-20 μM; 12 h) effectively promotes the accumulation of lipid ROS^[1].
Anticancer agent 193 (D3-3) remarkably increases the level of ferrous iron in HCT-116 cells in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HCT-116 cells
Concentration:

2.5 μM, 5 μM, 7.5 μM,10 μM, 15 μM, 30 μM
Incubation Time:

12, 24, and 48 h
Result:

Inhibited the proliferation of human colon cancer cells.

Western Blot Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

5 μM, 10 μM, 20 μM
Incubation Time:

12 h
Result:

Induced ferritinophagy in HCT-116 cells through the LC3-NCOA4-FTH1 axis.

In Vivo

Anticancer agent 193 (D3-3; 30-60 mg/kg; i.p; daily; for 2 weeks) restraines tumor growth and promoted lipid peroxidation in the HCT-116 xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female BALB/c nude mice injected with HCT-116 cells^[1]
Dosage:

30 mg/kg or 60 mg/kg
Administration:

i.p; daily; for 2 weeks
Result:

Inhibited tumor growth in vivo.

Chemical Information

Molecular Weight 615.20
Formel C₃₄H₄₇ClN₂O₆
SMILES

O=C(CCCCCCCCCCCNC(C(Cl)=C)=O)OC1=C2C(C[C@H](N(C)CC3)[C@](C=C4OC)([H])[C@@]23CC4=O)=CC=C1OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ling Zhu, et al. Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer. Eur J Med Chem. 2024 Feb 21:268:116250. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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