ULK1/2-IN-1
ULK1/2-IN-1 is a tissue-targeted ULK1/2 inhibitor conjugated to the RGR (CRGRRST) tumor neovasculature-homing peptide. ULK1/2-IN-1 mediates autophagy inhibition and induces cytotoxicity in endothelial cells. ULK1/2-IN-1 can be used for the research of tumor-targeted autophagy inhibitors.
For research use only. We do not sell to patients.
- Formula: C55H86F3N21O15S
- Molecular Weight:1370.46
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
ULK1 |
ULK2 |
ULK1/2-IN-1 (Compound 44) (2.5 μM; 18 h) shows cytotoxicity in HUVECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:human umbilical vein endothelial cells (HUVECs)
-
Concentration:2.5 μM
-
Incubation Time:4 h, 18 h
-
Result:Exhibited cytotoxicity in HUVECs at the 18 h, with variable results across replicates.
Chemical Information
-
Molecular Weight 1370.46
-
Formula C55H86F3N21O15S
-
SMILES
C[C@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(COCCOCCOCC(N1CC2=C(CC1)C=C(C=C2)NC3=NC=C(C(NC4CC4)=N3)C(F)(F)F)=O)=O)CS)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)C(O)=O)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz