1. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  2. PROTACs EGFR
  3. MS9427 TFA

MS9427 TFA is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 TFA potently inhibits the proliferation of NSCLC cells. MS9427 TFA can be used for researching anticancer.

For research use only. We do not sell to patients.

MS9427 TFA Chemical Structure

MS9427 TFA Chemical Structure

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1 mg USD 160 In-stock
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2600 In-stock
100 mg USD 4000 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MS9427 TFA is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 TFA potently inhibits the proliferation of NSCLC cells. MS9427 TFA can be used for researching anticancer[1].

In Vitro

MS9427 TFA has antiproliferative activity against HCC-827 cells, with a GI50 of 0.87 ± 0.27 μM[1].
MS9427 TFA (0-10 μM, 16 h) potently induces EGFRDel19 degradation (DC50=82 ± 73 nM) and inhibits EGFR phosphorylation (p-EGFR) in a concentration-dependent manner in HCC-827 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HCC-827 cells
Concentration: 1, 10, 50, 100, 200, 500, 100, and 10000 nM
Incubation Time: 16 h
Result: Inhibited EGFR phosphorylation (p-EGFR) in a concentration-dependent manner in HCC-827 cells.

Western Blot Analysis[1]

Cell Line: HCC-827 cells
Concentration: 100 nM
Incubation Time: 1, 2, 4, 6, 12, 24, 48 h
Result: Induced EGFR degradation in a time-dependent manner and through the UPS and autophagy/lysosome system.
Molecular Weight

1107.50

Formula

C50H59ClF4N8O14

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(NCCOCCOCCOCCOCCOCCC(N4CCN(CCCOC5=CC6=C(NC7=CC=C(F)C(Cl)=C7)N=CN=C6C=C5OC)CC4)=O)=C3)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MS9427 TFA
Cat. No.:
HY-147941A
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