Akt/mTOR-IN-1
Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- Formula: C31H21F3N2O3
- Molecular Weight:526.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Caspase 3 |
Akt/mTOR-IN-1 (10 μM, 72 h) exhibits effective inhibitory activity in HepG2, MCF-7, and MDA-MB-231 cells[1]. Akt/mTOR-IN-1 (2 μM, 12 h) induces autophagy cell death and apoptosis via AKT/mTOR signaling pathway in non-small cell lung cancer (NSCLC) A549 cells[1]. Akt/mTOR-IN-1 (0.3125-10 μM, 24 h) induces G2/M cell cycle arrest and apoptosis in non-small cell lung cancer (NSCLC) A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells, MDA-MB-231 cells, HepG2 cells
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Concentration:10 μM
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Incubation Time:72 h
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Result:Inhibited the proliferation of cancer cell lines. The IC50 values for HepG2, MCF-7, and MDA-MB-231 cells were 1.3, 0.5, and 0.8, respectively.
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Cell Line:Non-small cell lung cancer (NSCLC) A549 cells
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Concentration:0.3125, 0.625, 1.25, 2.5, 5, 10 μM
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Incubation Time:24 h
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Result:Led to G2/M cell cycle arrest.
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Cell Line:Non-small cell lung cancer (NSCLC) A549 cells
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Concentration:0.5, 1, 5, 10 μM
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Incubation Time:12 h
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Result:Could increase LC3B-II protein level and decrease Lamp1 protein level in a dose-dependent manner.
Chemical Information
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Molecular Weight 526.51
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Formula C31H21F3N2O3
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SMILES
O=C1NC(C2(O)C=CC(C=C2)=O)=C(C3=CC=C(C(F)(F)F)C=C3)C4=C1N(CC5=CC=CC=C5)C6=C4C=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Akt/mTOR-IN-1 Related Classifications
HY-161857 Related Classifications
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