1. Apoptosis
    Autophagy
  2. Apoptosis
    Autophagy
  3. 3'-Hydroxypterostilbene

3'-Hydroxypterostilbene 

Cat. No.: HY-N6002 Purity: 98.95%
Handling Instructions

3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.

For research use only. We do not sell to patients.

3'-Hydroxypterostilbene Chemical Structure

3'-Hydroxypterostilbene Chemical Structure

CAS No. : 475231-21-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 109 In-stock
Estimated Time of Arrival: December 31
5 mg USD 99 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
20 mg USD 286 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1].

IC50 & Target

Apoptosis[1]
Autophagy[1]

Molecular Weight

272.30

Formula

C₁₆H₁₆O₄

CAS No.

475231-21-1

SMILES

COC1=CC(/C=C/C2=CC=C(O)C(O)=C2)=CC(OC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 260 mg/mL (954.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6724 mL 18.3621 mL 36.7242 mL
5 mM 0.7345 mL 3.6724 mL 7.3448 mL
10 mM 0.3672 mL 1.8362 mL 3.6724 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (7.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (7.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (7.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

3'-HydroxypterostilbeneApoptosisAutophagyInhibitorinhibitorinhibit

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3'-Hydroxypterostilbene
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HY-N6002
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