Nampt-IN-3
Based on 1 Customer Validation
Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death.
For research use only. We do not sell to patients.
- Purity: 98.97%
- CAS No.: 2121591-52-2
- Formula: C29H25N7O2
- Molecular Weight:503.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
2.4 μM
Compound: 35
|
Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 28885834] |
| HepG2 | IC50 |
4.5 μM
Compound: 35
|
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 28885834] |
| MDA-MB-231 | IC50 |
10 μM
Compound: 35
|
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 28885834] |
Chemical Information
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CAS No. 2121591-52-2
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Appearance Solid
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Molecular Weight 503.55
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Formula C29H25N7O2
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Color White to off-white
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SMILES
O=C(C1=CC=C(C2=CN(CC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)N=N2)C=C1)NCC5=CC=CN=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 130 mg/mL (258.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9859 mL | 9.9295 mL | 19.8590 mL | 49.6475 mL |
| 5 mM | 0.3972 mL | 1.9859 mL | 3.9718 mL | 9.9295 mL | |
| 10 mM | 0.1986 mL | 0.9930 mL | 1.9859 mL | 4.9648 mL | |
| 15 mM | 0.1324 mL | 0.6620 mL | 1.3239 mL | 3.3098 mL | |
| 20 mM | 0.0993 mL | 0.4965 mL | 0.9930 mL | 2.4824 mL | |
| 25 mM | 0.0794 mL | 0.3972 mL | 0.7944 mL | 1.9859 mL | |
| 30 mM | 0.0662 mL | 0.3310 mL | 0.6620 mL | 1.6549 mL | |
| 40 mM | 0.0496 mL | 0.2482 mL | 0.4965 mL | 1.2412 mL | |
| 50 mM | 0.0397 mL | 0.1986 mL | 0.3972 mL | 0.9930 mL | |
| 60 mM | 0.0331 mL | 0.1655 mL | 0.3310 mL | 0.8275 mL | |
| 80 mM | 0.0248 mL | 0.1241 mL | 0.2482 mL | 0.6206 mL | |
| 100 mM | 0.0199 mL | 0.0993 mL | 0.1986 mL | 0.4965 mL |