2121591-52-2
2121591-52-2
Chemical Structure
Nampt-IN-3
- CAS No.: 2121591-52-2
- Formula:C29H25N7O2
- Molecular Weight:503.55
IUPAC Name: N-(2-aminophenyl)-4-((4-(4-((pyridin-3-ylmethyl)carbamoyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide
InChIKey: LSGNVZAEAAZOEH-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CN(CC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)N=N2)C=C1)NCC5=CC=CN=C5
Biological Activity: Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nampt-IN-3 | 98.97% | Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. | ||||||||||||||||||||
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Nampt-IN-3 (Standard) | ≥98% | Nampt-IN-3 (Standard) is the analytical standard of Nampt-IN-3 (HY-108701). This product is intended for research and analytical applications. Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.61
HY-123295HDAC3-IN-T247 -
Similarity Score 0.60
HY-162487HDAC-IN-72 -
Similarity Score 0.60
HY-12163Entinostat -
Similarity Score 0.59
HY-179216KTT-1 -
Similarity Score 0.59
HY-156422KPZ560 -
Similarity Score 0.58
HY-143294sEH inhibitor-2 -
Similarity Score 0.58
HY-12164Mocetinostat -
Similarity Score 0.58
HY-P11678HDAC-IN-100 -
Similarity Score 0.57
HY-173160HDAC1-IN-10 -
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