2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC1-IN-10

HDAC1-IN-10 (Compound 2b) is a potent, selective and orally active HDAC1/2 inhibitor with IC50 values of 6 and 190 nM. HDAC1-IN-10 shows IC50 > 50 μM for HDAC3-8. HDAC1-IN-10 can inhibit tumor growth in HCT-116 colon xenograft nude mice model. HDAC1-IN-10 can be used for research of colon cancer.

For research use only. We do not sell to patients.

HDAC1-IN-10

HDAC1-IN-10 Chemical Structure

CAS No. : 849233-98-3

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HDAC1-IN-10 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC1-IN-10 (Compound 2b) is a potent, selective and orally active HDAC1/2 inhibitor with IC50 values of 6 and 190 nM. HDAC1-IN-10 shows IC50 > 50 μM for HDAC3-8. HDAC1-IN-10 can inhibit tumor growth in HCT-116 colon xenograft nude mice model. HDAC1-IN-10 can be used for research of colon cancer[1].

IC50 & Target[1]

HDAC1

6 nM (IC50)

HDAC2

190 nM (IC50)

In Vitro

HDAC1-IN-10 can inhibit HCT-116 cells proliferation with an GI50 of 155 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC1-IN-10 Related Antibodies
Molecular Weight

458.53

Formula

C25H22N4O3S
CAS No.
SMILES

O=C(NCC1=CC=C(C(NC2=C(N)C=CC(C3=CC=CS3)=C2)=O)C=C1)OCC4=CC=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC1-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC1-IN-10849233-98-3HDACHistone deacetylasesInhibitorinhibitorinhibit

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