849233-98-3
849233-98-3
Chemical Structure
HDAC1-IN-10
- CAS. Nr.: 849233-98-3
- Formula:C25H22N4O3S
- Molecular Weight:458.53
IUPAC Name: pyridin-3-ylmethyl (4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzyl)carbamate
InChIKey: ASIJNKHQTPQFCQ-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(C(NC2=C(N)C=CC(C3=CC=CS3)=C2)=O)C=C1)OCC4=CC=CN=C4
Biological Activity: HDAC1-IN-10 (Compound 2b) is a potent, selective and orally active HDAC1/2 inhibitor with IC50 values of 6 and 190 nM. HDAC1-IN-10 shows IC50 > 50 μM for HDAC3-8. HDAC1-IN-10 can inhibit tumor growth in HCT-116 colon xenograft nude mice model. HDAC1-IN-10 can be used for research of colon cancer[1].
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HDAC1-IN-10 | HDAC1-IN-10 (Compound 2b) is a potent, selective and orally active HDAC1/2 inhibitor with IC50 values of 6 and 190 nM. HDAC1-IN-10 shows IC50 > 50 μM for HDAC3-8. HDAC1-IN-10 can inhibit tumor growth in HCT-116 colon xenograft nude mice model. HDAC1-IN-10 can be used for research of colon cancer. | |||||||||||||||||||||
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