Cearoin
Based on 1 Customer Validation
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.
For research use only. We do not sell to patients.
- Purity: 99.09%
- CAS No.: 52811-37-7
- Formula: C14H12O4
- Molecular Weight:244.24
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERK |
ROS |
Autophagy |
Apoptosis |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 21784631] |
| DU-145 | IC50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
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[PMID: 21784631] |
| J774.1 | IC50 |
15.4 μM
Compound: 13
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Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay
Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay
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[PMID: 15974608] |
| KB | IC50 |
35.33 μM
Compound: 4
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 21784631] |
Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1].
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1].
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neuroblastoma SH-SY5Y cells
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Concentration:0, 1, 5, 10, 20, 40, or 80 μM
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Incubation Time:6 or 12 hours
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Result:Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.
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Cell Line:Human neuroblastoma SH-SY5Y cells
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Concentration:0, 5, 10, 20, 40, or 80 μM
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Incubation Time:12 hours
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Result:Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner.
Chemical Information
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CAS No. 52811-37-7
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Appearance Solid
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Molecular Weight 244.24
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Formula C14H12O4
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Color Light yellow to green yellow
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SMILES
O=C(C1=CC(O)=C(OC)C=C1O)C2=CC=CC=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (204.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0943 mL | 20.4717 mL | 40.9433 mL | 102.3583 mL |
| 5 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL | 20.4717 mL | |
| 10 mM | 0.4094 mL | 2.0472 mL | 4.0943 mL | 10.2358 mL | |
| 15 mM | 0.2730 mL | 1.3648 mL | 2.7296 mL | 6.8239 mL | |
| 20 mM | 0.2047 mL | 1.0236 mL | 2.0472 mL | 5.1179 mL | |
| 25 mM | 0.1638 mL | 0.8189 mL | 1.6377 mL | 4.0943 mL | |
| 30 mM | 0.1365 mL | 0.6824 mL | 1.3648 mL | 3.4119 mL | |
| 40 mM | 0.1024 mL | 0.5118 mL | 1.0236 mL | 2.5590 mL | |
| 50 mM | 0.0819 mL | 0.4094 mL | 0.8189 mL | 2.0472 mL | |
| 60 mM | 0.0682 mL | 0.3412 mL | 0.6824 mL | 1.7060 mL | |
| 80 mM | 0.0512 mL | 0.2559 mL | 0.5118 mL | 1.2795 mL | |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0236 mL |
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