1. Autophagy
    Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    MAPK/ERK Pathway
    Apoptosis
  2. Autophagy
    ROS
    ERK
    Apoptosis
  3. Cearoin

Cearoin 

Cat. No.: HY-N8418
Handling Instructions

Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK.

For research use only. We do not sell to patients.

Cearoin Chemical Structure

Cearoin Chemical Structure

CAS No. : 52811-37-7

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Description

Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].

IC50 & Target[1]

ERK

 

ROS

 

Autophagy

 

Apoptosis

 

In Vitro

Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1].
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1].
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human neuroblastoma SH-SY5Y cells
Concentration: 0, 1, 5, 10, 20, 40, or 80 μM
Incubation Time: 6 or 12 hours
Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.

Western Blot Analysis[1]

Cell Line: Human neuroblastoma SH-SY5Y cells
Concentration: 0, 5, 10, 20, 40, or 80 μM
Incubation Time: 12 hours
Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner.
Molecular Weight

244.24

Formula

C₁₄H₁₂O₄

CAS No.

52811-37-7

SMILES

O=C(C1=CC(O)=C(OC)C=C1O)C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CearoinAutophagyROSERKApoptosisExtracellular signal regulated kinasesneuroblastomaautophagyreactiveoxygenspeciesSH-SY5YInhibitorinhibitorinhibit

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Product Name:
Cearoin
Cat. No.:
HY-N8418
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