SBP-1750
Based on 1 Customer Validation
SBP-1750 is an orally active ULK inhibitor and an ATG13 degrader. SBP-1750 strongly inhibits ULK1/2 activity, with IC50 values of 8 and 50 nM, respectively. SBP-1750 induces ATG13 degradation, with an EC50 value of 114 nM. SBP-1750 can inhibit autophagy in cancer cells and induce cell death. SBP-1750 can be used in cancer research, such as for pancreatic cancer.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 1884219-70-8
- Formula: C21H22ClN5O4
- Molecular Weight:443.88
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Anti-Cancer Compound Library
HY-L025
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Autophagy Compound Library
HY-L029
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Orally Active Compound Library
HY-L061
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Highly Selective Inhibitors Library
HY-L158
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Multi-Target Compound Library
HY-L176
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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ULK1 8 nM (IC50) |
ULK2 50 nM (IC50) |
SBP-1750 (5 μM; 18 hours) inhibits autophagy in A549 cells[1].
SBP-1750 (48 h) induces ATG13 degradation in A549 ATG13-HiBiT cells with EC50 of 114 nM[1].
SBP-1750 (48 h) inhibits cell viability in KRAS-mutant cancer cells (A549, MiaPaCa2, NCI-H358, PANC-1) with IC50 <50 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Tmax | Cmax | AUC0-t |
|---|---|---|---|---|---|---|
| Mice[1] | 10 mg/kg | p.o. | 2 h | 1 h | 32.9 μM | 135.42 μM/L·h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KPC4662 PDAC mice model[1]
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Dosage:40 mg/kg
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Administration:I.g., daily; from day 10 to 28
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Result:Inhibited tumor growth and metastasis to the liver and intestines.
Increaseed the infiltration of intratumoral CD4+ helper T cells and CD8+ cytotoxic T cells.
Chemical Information
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CAS No. 1884219-70-8
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Appearance Solid
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Molecular Weight 443.88
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Formula C21H22ClN5O4
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Color White to off-white
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SMILES
O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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