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製品番号: HY-111287

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Autophagonizer

(別名: DK-1-49)

Autophagonizer (DK-1-49) is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and enhances levels of autophagosomes and acidic vacuoles. Autophagonizer inhibits cell viability and induces cell death in not only cancer cells but also Bax/Bak double-knockout cells with EC₅₀ values of 3-4 μM.

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CAS 番号: 853136-76-2
分子式: C₂₈H₃₁N₅O₃S₂
分子量:549.71

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Autophagonizer 構造式

CAS 番号: 853136-76-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	1.3 μM Compound: DK-1-49	Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay	[PMID: 27597252]
HeLa	EC₅₀	3.5 μM Compound: DK-1-49	Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay	[PMID: 27597252]
HeLa	EC₅₀	3.5 μM Compound: DK-1-49	Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay	[PMID: 27597252]
MEF	EC₅₀	2.1 μM Compound: DK-1-49	Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay	[PMID: 27597252]
MEF	EC₅₀	2.2 μM Compound: DK-1-49	Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay	[PMID: 27597252]

化学情報

CAS 番号 853136-76-2
分子量 549.71
分子式 C₂₈H₃₁N₅O₃S₂
SMILES

O=C(C1=COC(CSC2=NC3=C(C4=C(CCCC4)S3)C(N2CC5=CC=CC=C5)=O)=N1)NCCN6CCCC6
別名

DK-1-49
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Nguyen J, et al. Facile synthesis of autophagonizer and evaluation of its activity to induce autophagic cell death in apoptosis-defective cell line. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4753-4756. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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